Publications by authors named "B Gole"
Artificial molecules that respond to external stimuli such as light, heat, chemical signals, and mechanical force have garnered significant interest due to their tunable functions, variable optical properties, and mechanical responses. Particularly, mechanoresponsive materials featuring molecules that respond to mechanical stress or show force-induced optical changes have been intriguing due to their extraordinary functions. Despite the promising potential of many such materials reported in the past, practical applications have remained limited, primarily because their functions often depend on irreversible covalent bond rupture.
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- Integrating anthracene structures into oligoamide sequences creates photoactive molecules known as foldamers that can capture a thread, forming a helical structure.
- When exposed to light, these helix-on-axle assemblies change shape, causing the thread to be released and producing a measurable light output.
- The original assembly can be restored through a heating process, demonstrating a reversible action in response to light and temperature changes.
Article Synopsis
- * The study utilized single-cell RNA sequencing on PBMC samples from CD patients to identify gene expression signals that may be hidden due to therapy or inflammation, employing rigorous methods for gene selection and validation.
- * Key findings revealed significant candidate genes in CD4 T cells and double-negative T cells that were associated with responses to anti-TNFα therapy, offering insights that could improve personalized treatment strategies for CD patients.
This study aimed to measure and compare the osmolality and tonicity of isotonic beverages that can be bought on the Slovenian market. The main goal was to examine how good is the agreement between the measured osmolalities of the beverages and the requirements for isotonic beverages set up by EFSA. Osmolalities were measured with an osmometer using the freezing point depression method.
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- Researchers studied how certain genes affect Crohn's disease patients' response to adalimumab (an anti-TNFα treatment) and identified the MMD gene as a potential biomarker for therapy effectiveness.
- They isolated monocytes from patients who did and didn’t respond to the treatment, and then turned those into macrophages to observe how they react to inflammation and adalimumab in a lab setting.
- The findings showed that non-responders had higher levels of inflammatory cytokines, particularly IL1B, suggesting that IL1B expression in macrophages could serve as a reliable biomarker to predict adalimumab response in Crohn's disease patients.