High resolution imaging of craniofacial bone specimens by flat-panel volumetric computed tomography.

Introduction: The prototype flat-panel volumetric computed tomograph (fpvCT) provides a new 3D imaging technology with detailed high resolution by using large-area flat-panel X-ray detectors. The object of this study was to evaluate the benefit of high resolution imaging using the experimental fpvCT to visualise different types of human craniofacial bone pathology. The study proved the feasibility of performing an intraoperative evaluation of free margins in bone malignancies using fpvCT.

Vitamin D receptor genotypes are not associated with rheumatoid arthritis or biochemical parameters of bone turnover in German RA patients.

Objective: Vitamin D is known to exert immunomodulatory effects. An overrepresentation of the b allele of the vitamin D receptor (VDR) has been detected in autoimmune diseases as type-1-diabetes and multiple sclerosis. VDR polymorphisms have been shown to influence bone metabolism and bone density.

VDR gene polymorphisms are overrepresented in german patients with type 1 diabetes compared to healthy controls without effect on biochemical parameters of bone metabolism.

Type 1 diabetic individuals are known to develop disorders of bone metabolism resulting in osteopenia. Previous studies have suggested an influence of vitamin D receptor alleles on bone metabolism and susceptibility for type 1 diabetes mellitus. The present study was initiated to investigate the distribution of vitamin D receptor alleles in Caucasian type 1 diabetic patients and their relation to bone turnover parameters.

Effect of ethanol on rat brain protein synthesis. I. Acute administration.

The addition of ethanol to cell free protein synthesizing systems from the rat brain in vitro did not influence the incorporation of labeled amino acids into acid precipitable protein within a concentration range up to 10 mM. But in vivo acute administration of the drug to naive animals induced an activation of protein synthesis by cytoplasmic ribosomes isolated from the cerebral cortex and cerebellum. By contrast, incorporation of amino acids into mitochondrial or synaptosomal protein remained unchanged.