Publications by authors named "B Gnana Prakash"
High apolipoprotein B-containing (apoB-containing) low-density lipoproteins (LDLs) and low apoA1-containing high-density lipoproteins (HDLs) are associated with atherosclerotic cardiovascular diseases. In search of a molecular regulator that could simultaneously and reciprocally control both LDL and HDL levels, we screened a microRNA (miR) library using human hepatoma Huh-7 cells. We identified miR-541-3p that both significantly decreases apoB and increases apoA1 expression by inducing mRNA degradation of 2 different transcription factors, Znf101 and Casz1.
View Article and Find Full Text PDFBackground and objective Beta-blockers are a cornerstone in the management of acute coronary syndrome (ACS), effectively reducing myocardial oxygen demand, preventing recurrent ischemia, and lowering the risk of arrhythmias and reinfarction. Despite several established guidelines, such as those by the American College of Cardiology/American Heart Association (ACC/AHA), advocating their use within 24 hours for eligible patients, beta-blockers remain underutilized in clinical practice. This study aimed to analyze beta-blocker utilization patterns in ACS management and evaluate the impact of targeted improvement initiatives on their appropriate use in eligible ACS patients.
View Article and Find Full Text PDFBackground: Sleep-disordered breathing (SDB) is characterized by upper airway dysfunction and is linked to severe health issues. Individuals with SDB have distinct craniofacial morphology for which orthodontists are most suitable for the management due to their dental expertise.
Aim: This study aims to discern key differences in dental parameters between individuals with and without SDB.
Understanding obesity among young adults in India: A focus group study.
Diabetes Metab Syndr
September 2024
Article Synopsis
- The study investigates young adults in India, focusing on their knowledge of obesity risks, motivation for weight loss, and barriers they face in managing their weight.
- Six focus group discussions were held with obese young adults aged 18-30, using varied sampling methods to gather diverse insights on obesity.
- Findings revealed a need for greater awareness about obesity, identified physical appearance and social support as key motivators for weight loss, and suggested a holistic approach including dietary changes and educational reforms to combat obesity among young adults.
Background: The association between somatic symptoms and psychiatric co-morbidities remains unexplored among patients with medically unexplained physical symptoms (MUPS) in Asian populations. This study aims to bridge this gap by investigating psychiatric morbidities and their determinants among patients presenting with MUPS in an Indian setup.
Methodology: This cross-sectional study, conducted in the outpatient department (OPD) of a tertiary care hospital in India, assessed 200 patients diagnosed with MUPS.