One-step vs 2-step gestational diabetes mellitus screening and pregnancy outcomes: an updated systematic review and meta-analysis.

Objective: This was a systematic review and meta-analysis comparing maternal and neonatal outcomes of patients screened with the 1-step or 2-step screening method for gestational diabetes mellitus.

Data Sources: PubMed, Scopus, Cochrane, ClinicalTrials.gov, and LILACS were searched from inception up to September 2022.

Inhibition of Phosphatidylinositol 3-Kinase by Pictilisib Blocks Influenza Virus Propagation in Cells and in Lungs of Infected Mice.

Influenza virus (IV) infections are considered to cause severe diseases of the respiratory tract. Beyond mild symptoms, the infection can lead to respiratory distress syndrome and multiple organ failure. Occurrence of resistant seasonal and pandemic strains against the currently licensed antiviral medications points to the urgent need for new and amply available anti-influenza drugs.

Surface precipitation of Mn on clay minerals enhances Cd sorption under anoxic conditions.

The influence of Mn on the sorption of metal(loid)s onto clay minerals is still unclear despite its relevance in suboxic and anoxic environments which often exhibit elevated dissolved Mn concentrations. In this study, the effects of Mn on Cd sorption to two types of clay minerals, a well-crystalline natural kaolinite (KGa-1b) and a synthetic montmorillonite (Syn-1), were investigated. Batch experiments on Mn and Cd sorption to Ca-saturated KGa-1b and Syn-1 were conducted under anoxic conditions.

Lung Infection Results in Down-Regulation of Surfactant Protein-A Mainly Caused by Pro-Inflammatory Macrophages.

Pneumonia is the leading cause of hospitalization worldwide. Besides viruses, bacterial co-infections dramatically exacerbate infection. In general, surfactant protein-A (SP-A) represents a first line of immune defense.