Publications by authors named "B Giuliani"
Introduction: The ongoing emergence of SARS-CoV-2 variants poses significant challenges to existing therapeutics. The spike (S) glycoprotein is central to both viral entry and cell-to-cell transmission via syncytia formation, a process that confers resistance to neutralizing antibodies. The mechanisms underlying this resistance, particularly in relation to spike-mediated fusion, remain poorly understood.
View Article and Find Full Text PDFCancer is a highly heterogeneous disease, where phenotypically distinct subpopulations coexist and can be primed to different fates. Both genetic and epigenetic factors may drive cancer evolution, however little is known about whether and how such a process is pre-encoded in cancer clones. Using single-cell multi-omic lineage tracing and phenotypic assays, we investigate the predictive features of either tumour initiation or drug tolerance within the same cancer population.
View Article and Find Full Text PDFArticle Synopsis
- SARS-CoV-2, a virus responsible for COVID-19, interacts with host cell proteins to both inhibit and promote its own replication, yet many of these interactions remain unclear.
- Researchers used advanced techniques to identify host proteins that specifically bind to crucial regions of the SARS-CoV-2 RNA, focusing on a protein called PUS7.
- Their findings reveal significant post-transcriptional modifications in the viral RNA and suggest that understanding these interactions could lead to new treatment strategies for COVID-19.
Background: Elective splenectomy is the main treatment for a wide range of haematological diseases. Porto-spleno-mesenteric venous thrombosis represents one of the most severe complications of this procedure. The aim of this study was to evaluate risk factors associated with development of porto-spleno-mesenteric venous thrombosis after elective splenectomy.
View Article and Find Full Text PDFThe landscape of pervasive transcription in eukaryotic genomes has made space for the identification of thousands of transcripts that are difficult to frame in a specific functional category. A new class has been broadly named as long non-coding RNAs (lncRNAs) and shortly defined as transcripts that are longer than 200 nucleotides with no or limited coding potential. So far, about 19,000 lncRNAs genes have been annotated in the human genome (Gencode 41), nearly matching the number of protein-coding genes.
View Article and Find Full Text PDF