Hydrolysis of Dimethyl Phosphite by Zr- and Hf-UiO-66.

Metal-organic frameworks have been utilized as heterogeneous catalysts for the degradation of chemical warfare agents, typically organophosphorous nerve agents. Vibrational spectroscopy techniques coupled with nuclear magnetic resonance (NMR) were utilized to study the adsorption and degradation of dimethyl phosphite (DMP), a simulant molecule of the organophosphorus nerve agent Soman (GD), by Zr- and Hf-UiO-66 as a function of particle size, defect type, and defect density. Defective Zr- and Hf-UiO-66 have been synthesized via a modulated synthesis protocol to engineer missing linker and missing cluster defects into the crystal structure.

Macromorphological Control of Zr-Based Metal-Organic Frameworks for Hydrolysis of a Nerve Agent Simulant.

Zirconium-based metal-organic frameworks (MOFs) have become one of the most promising materials for the adsorption and destruction of chemical warfare agents. While numerous studies have shown differences in reactivity based on MOF topology and postsynthetic modification, the understanding of how modifying MOF macromorphology is less understood. MOF xerogels demonstrate modified defect levels and larger porosity, which increase the number of and access to potential active sites.

Exploring Ion Mobility Mass Spectrometry Data File Conversions to Leverage Existing Tools and Enable New Workflows.

Ion mobility (IM) is often combined with LC-MS experiments to provide an additional dimension of separation for complex sample analysis. While highly complex samples are better characterized by the full dimensionality of LC-IM-MS experiments to uncover new information, downstream data analysis workflows are often not equipped to properly mine the additional IM dimension. For many samples the data acquisition benefits of including IM separations are all that is necessary to uncover sample information and the full dimensionality of the data is not required for data analysis.

Collaborative care approaches for people with severe mental illness.

Background: Collaborative care for severe mental illness (SMI) is a community-based intervention that promotes interdisciplinary working across primary and secondary care. Collaborative care interventions aim to improve the physical and/or mental health care of individuals with SMI. This is an update of a 2013 Cochrane review, based on new searches of the literature, which includes an additional seven studies.