Organoid-based systems to model infection in 2D and 3D.

Typical cancer cell-based culture systems cannot support the full life cycle of , despite its monoxenous life cycle which is completed in the small intestine of a single host. There is a block to fertilization and zygote formation . In this paper, we adapted a 2D organoid derived monolayer system and a 3D inverted enteroid system for use in culture.

Visual noise effect on reading in three developmental disorders: ASD, ADHD, and DD.

Background And Aims: Developmental disorders such as Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD), and Developmental Dyslexia (DD) are reported to have more visual problems, oral language difficulties, and diminished reading skills in addition to their different diagnostic features. Moreover, these conditions also have increased internal noise and probably an impaired ability of external noise filtering. The aim of the present study was to compare the reading performance of these groups in the presence of external visual noise which disrupts the automatic reading processes through the degradation of letters.

FT-NIR Spectroscopy for the Non-Invasive Study of Binders and Multi-Layered Structures in Ancient Paintings: Artworks of the Lombard Renaissance as Case Studies.

This work deals with the identification of natural binders and the study of the complex stratigraphy in paintings using reflection FT-IR spectroscopy, a common diagnostic tool for cultural heritage materials thanks to its non-invasiveness. In particular, the potential of the near-infrared (NIR) spectral region, dominated by the absorption bands due to CH, CO, OH and NH functional groups, is successfully exploited to distinguish a lipid binder from a proteinaceous one, as well as the coexistence of the two media in laboratory-made model samples that simulate the complex multi-layered structure of a painting. The combination with multivariate analysis methods or with the calculation of indicative ratios between the intensity values of characteristic absorption bands is proposed to facilitate the interpretation of the spectral data.

The Impact of Different Timing Schedules on Prostate HDR-Mono-Brachytherapy. A TCP Modeling Investigation.

Background: Mechanistic TCP (tumor control probability) models exist that account for possible re-sensitization of an initially hypoxic tumor during treatment. This phenomenon potentially explains the better outcome of a 28-day vs 14-day treatment schedule of HDR (high dose rate) brachytherapy of low- to intermediate-risk prostate cancer as recently reported.

Methods: A TCP model accounting for tumor re-sensitization developed earlier is used to analyze the reported clinical data.