Publications by authors named "B Gasnier"
The lysosomal degradation of macromolecules produces diverse small metabolites exported by specific transporters for reuse in biosynthetic pathways. Here we deorphanized the major facilitator superfamily domain containing 1 (MFSD1) protein, which forms a tight complex with the glycosylated lysosomal membrane protein (GLMP) in the lysosomal membrane. Untargeted metabolomics analysis of MFSD1-deficient mouse lysosomes revealed an increase in cationic dipeptides.
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- Lysosomes are like recycling centers in cells; they break down damaged parts and help reuse nutrients.
- A special protein called PQLC2 helps move certain nutrients in and out of lysosomes and signals when the cell needs more food.
- Scientists studied how PQLC2 works and found that it has a unique way of transporting nutrients which can be affected by another nutrient called arginine, making it act a bit differently than expected.
Plug-and-socket mechanisms in nutrient sensing by lysosomal amino acid transporters.
Proc Natl Acad Sci U S A
March 2021
Sialin, encoded by the gene, is a lysosomal sialic acid transporter defective in Salla disease, a rare inherited leukodystrophy. It also enables metabolic incorporation of exogenous sialic acids, leading to autoantibodies against -glycolylneuraminic acid in humans. Here, we identified a novel class of human sialin ligands by virtual screening and structure-activity relationship studies.
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