Publications by authors named "B Gardlund"
Purpose: Septic shock is a highly heterogeneous condition which is part of the challenge in its diagnosis and treatment. In this study we aim to identify clinically relevant subphenotypes of septic shock using a novel statistic al approach.
Methods: Baseline patient data from a large global clinical trial of septic shock (n = 1696) was analysed using latent class analysis (LCA).
Purpose: Few reports have been published on the optimal duration of treatment of ocular candidiasis. We have investigated the incidence of late-onset Candida chorioretinitis and endophthalmitis in patients with candidemia who did not initially receive an ophthalmologic examination. The aim was to determine the duration of initial antifungal treatment that may be sufficient to avoid this complication.
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- In sepsis, a high release of inflammatory cytokines occurs, but the exact cellular source is still unclear.
- Researchers used a specific technique to analyze cytokine production from blood cells in 32 septic patients and 30 healthy controls, finding that septic patients had fewer cytokine-secreting cells in response to LPS stimulation.
- The findings suggest that circulating leukocytes are not responsible for the elevated plasma cytokine levels seen in sepsis, indicating a complex regulation of cytokine secretion related to the severity of the condition.
Background: Severe sepsis is a common condition with a reported high mortality, but most studies have been confined to intensive care unit (ICU) populations. The systemic inflammatory response syndrome (SIRS) has been used to define sepsis, however its usefulness has been questioned. Our aim was to describe the prevalence and clinical impact of severe sepsis and SIRS in patients admitted from the emergency department (ED) with a suspected serious infection.
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