Publications by authors named "B Ganetzky"
Traumatic brain injury (TBI) outcomes vary greatly among individuals, but most of the variation remains unexplained. Using a Drosophila melanogaster TBI model and 178 genetically diverse lines from the Drosophila Genetic Reference Panel (DGRP), we investigated the role that genetic variation plays in determining TBI outcomes. Following injury at 20-27 days old, DGRP lines varied considerably in mortality within 24 h ("early mortality").
View Article and Find Full Text PDFArticle Synopsis
- Traumatic brain injury (TBI) can lead to issues like increased intestinal permeability, and studies show that the beta-blocker drug labetalol can help reduce this effect in rats.
- Research using a fly model of TBI found that feeding flies beta-blockers (labetalol and metoprolol) decreased intestinal permeability, but only metoprolol showed an effect when analyzing multiple fly lines, and neither drug affected mortality rates.
- The findings suggest that the relationship between disrupted intestinal barriers and TBI is similar across species, highlighting the utility of flies as a model for understanding how brain and intestinal signaling is affected after TBI in humans.
Traumatic brain injury (TBI) is a common neurological disorder whose outcomes vary widely depending on a variety of environmental factors, including diet. Using a Drosophila melanogaster TBI model that reproduces key aspects of TBI in humans, we previously found that the diet consumed immediately following a primary brain injury has a substantial effect on the incidence of mortality within 24 h (early mortality). Flies that receive equivalent primary injuries have a higher incidence of early mortality when fed high-carbohydrate diets versus water.
View Article and Find Full Text PDF