Publications by authors named "B Galmes"
The stability and hydrolytic behavior of squaramate esters in aqueous solutions have been investigated. The structure of squaramates and the nature of adjacent groups significantly influence their aqueous stability and reactivity towards nucleophiles. Squaramate esters, lacking or containing weakly basic neighboring group participation (NGP) substitutions, remain stable up to pH 9.
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- A retrospective study in Spain and Portugal evaluated the real-world effectiveness of lonoctocog alfa (rVIII-SingleChain), a long-acting factor VIII therapy, in patients with hemophilia A who switched from other treatments.
- Among 29 patients, there was a significant increase in those requiring fewer weekly infusions (from 37.5% to 60.7%) and an improvement in bleeding control, with total bleeds reducing from 50 to 33 after the switch.
- Overall, patients experienced excellent safety and efficacy, leading to improved quality of life without any reported safety issues.
Sulfate-induced large amplitude conformational change in a Solomon link.
Chem Commun (Camb)
October 2023
A doubly-interlocked [2]catenane - or Solomon link - undergoes a complex conformational change upon addition of sulfate in methanol. This transformation generates a single pocket where two SO anions bind through multiple hydrogen bonds and electrostatic interactions. Despite the close proximity of the two anions, binding is highly cooperative.
View Article and Find Full Text PDFThe co-crystallization of tetracyanobenzene (TCB) with haloarenes ArX provided six new co-crystals TCB ⋅ ArX (ArX=PhCl, PhBr, 4-MeC H Cl, 4-MeC H Br, 4-MeOC H Cl, 1,2-Br C H ) which were studied by X-ray diffraction. In these systems, the strong collective effect of π⋅⋅⋅π stacking interactions and lone pair-(X)⋅⋅⋅π-hole-(C) bondings between TCB and ArX promote the strength of X⋅⋅⋅N halogen bonding (HaB). Theoretical studies showed that the stacking interactions affect the σ-hole depth of the haloarenes, thus significantly boosting their ability to function as HaB donors.
View Article and Find Full Text PDFObjective: To evaluate the efficacy and safety of a plasma-derived factor VIII concentrate containing von Willebrand Factor (pdVWF/FVIII) in standard clinical practice in von Willebrand Disease (VWD) patients.
Methods: A retrospective, multicentric, observational study of VWD patients treated with Fanhdi, a pdVWF/FVIII concentrate, from January 2011 to December 2017 was conducted at 14 centers in Spain. Efficacy and safety were evaluated for acute bleeding episodes, for prevention of bleeding in surgeries, and for secondary long-term prophylaxis.