Publications by authors named "B Gaire"
Article Synopsis
- Pathological tau isoforms, particularly hyperphosphorylated tau at serine 396, and tau oligomers were found in the retinas of patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD), indicating a potential link between tauopathy and retinal changes.
- The study analyzed retinal cross-sections from 25 patients with MCI or AD and 16 cognitively normal controls, revealing a significant reduction in retinal ganglion cells (RGCs) and increased signs of cell distress in MCI and AD patients compared to controls.
- Findings showed that higher amounts of pS396-tau in RGCs were strongly correlated with decreased RGC integrity and related to severity in cognitive decline, suggesting that retinal
Naturally occurring homoisoflavonoids isolated from some Liliaceae plants have been reported to have diverse biological activities (e.g., antioxidant, anti-inflammatory, and anti-angiogenic effects).
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- Recent advancements in Alzheimer's disease (AD) diagnostics and treatments show promise, but there's still a significant need for effective therapies, indicating that more research is essential.
- Evidence suggests that microbial infections could play a role in AD, with specific bacteria like Chlamydia pneumoniae (Cp) being frequently found in the brains of AD patients.
- Despite its presence in AD brains, there is currently no conclusive research proving whether Cp directly causes or contributes to AD progression, prompting a discussion of potential mechanisms connecting Cp to AD pathology.
Article Synopsis
- The retina is being studied as a promising, noninvasive way to diagnose and track Alzheimer's disease (AD) because it shows similar pathological features to those found in the brain, like amyloid and tau protein abnormalities.
- Research has found that structural and functional issues in the retina, including reduced blood flow and inflammation, correlate with the severity of AD symptoms in patients.
- Advanced imaging technologies are now capable of detecting AD-related changes in the retina, which could help in early diagnosis and monitoring of the disease, but more studies are needed with larger, diverse groups to confirm these findings and improve screening methods.