Publications by authors named "B Gachot"
J Proteome Res
November 2024
Article Synopsis
- Circulating proteomes can reveal the body's response to diseases like COVID-19 and treatments like tocilizumab, which is used to mitigate severe symptoms.
- In a study involving 28 hospitalized COVID-19 patients treated with tocilizumab, researchers collected serum samples to analyze changes in protein levels before and after treatment and assessed patient outcomes for 30 days.
- Findings indicated that specific proteins related to the complement system and Fc-epsilon receptor signaling could predict treatment success and mortality, where high complement activation linked to worse outcomes and certain signaling pathways showed lower mortality rates.
Article Synopsis
- The study investigates how memory T cells respond to the SARS-CoV-2 virus and its variants, focusing on their link to protection against COVID-19 in healthy and cancer patients.
- Findings suggest that an imbalance in immune responses, particularly between type 1 and type 2 cytokines, increases vulnerability to the virus, especially in individuals with specific deficiencies in T helper 1 (Th1) cells.
- Current vaccines primarily trigger Th1 responses effectively against the original virus strain, highlighting the need for future vaccines to target T-cell responses against the receptor binding domain of new variants.
