Publications by authors named "B G Wren"
is the leading cause of bacterial gastroenteritis and is a major public health concern worldwide. Despite its importance, our understanding of how causes diarrhoea and interacts with its hosts is limited due to the absence of appropriate infection models and established virulence factors found in other enteric pathogens. Additionally, despite its genetic diversity, non-pathogenic strains are unknown.
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- Virulence studies on the one-carbon metabolism pathway and proline synthesis indicate their importance in the infection process, particularly in Δ and Δ mutant strains of capsular serotype 6B BHN418.* -
- These mutant strains showed significantly reduced virulence in models of mouse sepsis and pneumonia despite being able to colonize the nasopharynx and grow normally in nutrient-rich environments.* -
- Differences in metabolic profiles and gene transcription under various stress conditions revealed strain-specific effects on virulence and metabolism, underscoring the need for rapid adaptation to host physiological conditions.*
Objectives: Patients with rheumatoid arthritis (RA) have an increased susceptibility to infections, including those caused by . Why RA is associated with increased susceptibility to is poorly understood. This study aims to assess the effects of RA and B-cell depletion therapy on naturally acquired antibody responses to 289 protein antigens using a novel protein array.
View Article and Find Full Text PDFAcanthamoeba, are ubiquitous eukaryotic microorganisms, that play a pivotal role in recognizing and engulfing various microbes during predation, offering insights into microbial dynamics and immune responses. An intriguing observation lies in the apparent preference of Acanthamoeba for Gram-negative over Gram-positive bacteria, suggesting potential differences in the recognition and response mechanisms to bacterial prey. Here, we comprehensively review pattern recognition receptors (PRRs) and microbe associated molecular patterns (MAMPs) that influence Acanthamoeba interactions with bacteria.
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- The study focuses on bacterial oligosaccharyltransferases (OSTs), particularly PglB from Campylobacter jejuni, which are important for glycoengineering and developing glycoconjugate vaccines.
- Researchers created a quick cell-free glycosylation assay to evaluate how different PglBs transfer various glycans to proteins, testing eleven PglBs from several Campylobacter species.
- Results showed that while PglBs from the same genus had similar transfer capabilities, those from different genera varied, with C. hepaticus and C. subantarcticus PglBs demonstrating high efficiency, indicating potential for vaccine development.