Publications by authors named "B G Weinshenker"
Background: We evaluated comprehension and application of the 2015 neuromyelitis optica spectrum disorder (NMOSD) criteria core elements by neurologists in Latin America (LATAM) who routinely diagnose and care for NMOSD patients by (i) identifying typical/suggestive NMOSD syndromes, (ii) detecting typical MRI NMOSD lesions and meeting MRI dissemination in space (DIS) criteria, and (iii) evaluating historical symptoms suggestive of NMOSD.
Methods: We conducted an anonymous, voluntary, self-administered web- and case-based survey cross-sectional study from October 2023 to January 2024 of neurologists identified through the LACTRIMS database. Questions were presented first through iterative clinical cases or imaging, followed by questions directly evaluating comprehension of definitions.
Cerebellar Involvement in Attacks of Aquaporin-4-IgG Positive Neuromyelitis Optica Spectrum Disorder.
Neurol Neuroimmunol Neuroinflamm
January 2025
Article Synopsis
- The study analyzes how often and in what way the cerebellum is affected during attacks of aquaporin-4-IgG positive neuromyelitis optica spectrum disorder (AQP4+NMOSD), which isn't fully covered by current diagnostic standards.
- Out of 432 AQP4+NMOSD patients, 17 (4%) showed cerebellar attacks with severe neurological symptoms, including high disability scores.
- MRI results indicated that most cerebellar lesions were found in the cerebellar peduncles and dentate nucleus, with many persisting beyond six months, suggesting that understanding these patterns is important for refining future diagnostic criteria for AQP4+NMOSD.
Article Synopsis
- * Researchers measured central motor conduction time (CMCT) in different groups, including MS patients with and without the McArdle sign, other myelopathy patients, and healthy controls.
- * Results showed that MS patients with a prominent McArdle sign displayed significantly prolonged CMCT during neck flexion, suggesting that the sign may be linked to nerve conduction slowing due to demyelination.
Introduction: Physical exercise (PE) improves symptoms and quality of life in people with multiple sclerosis (pwMS). However, incorporating PE into daily lives of pwMS pose difficulties. As an alternative to in-person PE, e-based PE has been proposed because of its advantages in terms of accessibility and convenience.
View Article and Find Full Text PDFThe differential diagnosis of multiple sclerosis can present specific challenges in patients from Latin America, Africa, the Middle East, eastern Europe, southeast Asia, and the Western Pacific. In these areas, environmental factors, genetic background, and access to medical care can differ substantially from those in North America and western Europe, where multiple sclerosis is most common. Furthermore, multiple sclerosis diagnostic criteria have been developed primarily using data from North America and western Europe.
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