Publications by authors named "B G Slavin"
Bone nonunion following a fracture represents a significant global healthcare challenge, with an overall incidence ranging between 2 and 10% of all fractures. The management of nonunion is not only financially prohibitive but often necessitates invasive surgical interventions. This comprehensive manuscript aims to provide an extensive review of the published literature involving growth factors, stem cells, and novel delivery mechanisms for the treatment of fracture nonunion.
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- Three-dimensional (3D) bioprinting has evolved as a groundbreaking technology in surgery, facilitating advancements in reconstructive and regenerative medicine over the past five years.
- Recent literature showcases innovations in creating complex, patient-specific tissues and organs that closely resemble natural tissue, enhancing surgical interventions.
- Despite significant progress, challenges remain such as vascularization, integration with existing tissues, and long-term viability, highlighting the need for continued research and regulatory support to maximize its clinical potential.
Preclinical evaluation of mucogingival defect treatment using piscine membranes: An in vivo assessment of wound healing.
J Biomed Mater Res B Appl Biomater
August 2024
Periodontitis is a bacteria-induced chronic inflammatory disease characterized by degradation of the supporting tissue and bone in the oral cavity. Treatment modalities seek to facilitate periodontal rehabilitation while simultaneously preventing further gingival tissue recession and potentially bone atrophy. The aim of this study was to compare two differently sourced membranes, a resorbable piscine collagen membrane and a porcine-derived collagen membrane, in the repair of soft tissue defects utilizing a preclinical canine model.
View Article and Find Full Text PDFThe use of porcine-derived collagen membranes (PDCM) to improve intraoral soft tissue rehabilitation remains under investigation. Different degrees of crosslinking have yielded differences in resorption time and inflammation surrounding collagen membranes. The aim of this study was to evaluate the in vivo performance of bilayered PDCMs with varying degrees of crosslinking for the regeneration of oral soft tissue defects.
View Article and Find Full Text PDFBone regeneration remains a significant clinical challenge, often necessitating surgical approaches when healing bone defects and fracture nonunions. Within this context, the modulation of adenosine signaling pathways has emerged as a promising therapeutic option, encouraging osteoblast activation and tempering osteoclast differentiation. A literature review of the PubMed database with relevant keywords was conducted.
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