Investigation into Drug-Induced Liver Damage Using Multimodal Mass Spectrometry Imaging.

Drug toxicity during the development of candidate pharmaceuticals is the leading cause of discontinuation in preclinical drug discovery and development. Traditionally, the cause of the toxicity is often determined by histological examination, clinical pathology, and the detection of drugs and/or metabolites by liquid chromatography-mass spectrometry (LC-MS). While these techniques individually provide information on the pathological effects of the drug and the detection of metabolites, they cannot provide specific molecular spatial information without additional experiments.

The impact of vascular injuries on the management of bile duct injury following laparoscopic cholecystectomy- insights from a prospective study.

Background: Our study aimed to compare the clinical presentation and outcomes of post-cholecystectomy bile duct injuries (BDI) with and without arterial injuries.

Methods: A prospective analysis of 123 patients with post-cholecystectomy BDI between July 2018 and January 2022 was performed. Multivariate logistic regression analysis was used to assess the impact of vascular injuries on perioperative complications and long-term outcomes after delayed repair.

Effectiveness of donor notification and counseling of HIV-reactive donors in a tertiary care hospital from North India: An audit.

Introduction: Blood banks are responsible for notification and counseling of the reactive donors besides screening for transfusion-transmitted infections (TTIs). Donor notification and counseling is essential to protect the health of the donor by early clinical intervention and to prevent secondary transmission of infection.

Aim: The aim of this study was to determine the effectiveness of human immunodeficiency virus (HIV)-reactive donor notification and counseling in a tertiary care center.

Loeffler's Syndrome Induced by the Transmigration of Strongyloides stercoralis to the Lungs: A Case Report and Literature Review.

Loeffler's syndrome is a rare, benign respiratory disease usually associated with peripheral eosinophilia, first described by Wilhelm Loeffler in 1932. It is caused by the larvae of helminths such as hookworms, , and S that transmigrate through the lungs during the active phase of infection. We present a case of a 53-year-old man who complained of a productive cough with intermittent hemoptysis and left-sided posterior chest pain.

Comparison of Lignocaine-Dexamethasone vs. Lignocaine-Triamcinolone for Preventing Post Spinal-Epidural Backache: A Randomized Study.

Background: The primary objective of this study was to compare the efficacy of lignocaine-dexamethasone and lignocaine-triamcinolone infiltration, along the spinal-epidural needle insertion pathway, to prevent backache after lower abdominal surgeries.

Methods: This prospective, double-blind randomized controlled study included a total of 150 patients, scheduled for elective lower abdominal surgery under combined spinal-epidural (CSE) anaesthesia. The patients were randomised into three groups Group L (Lignocaine, n=50), Group DL (Dexamethasone, Lignocaine, n=50), and Group TL (Triamcinolone, Lignocaine, n=50).