Publications by authors named "B G Sinclair"
Article Synopsis
- Hippocampal sclerosis (HS) is a major cause of temporal lobe epilepsy (TLE) but can be hard to detect on MRI, leading to surgical delays, so researchers created open-source software to improve diagnosis.
- The study involved 365 participants, using the software HippUnfold to analyze MRI scans and develop a logistic regression model that accurately identifies and localizes HS.
- The classifier showed high accuracy in detecting HS in both initial and independent patient cohorts, proving effective for individual assessments by comparing patient data with normative growth patterns.
Background: Process mining was widely used in healthcare settings to analyse patient pathways, providing insights about patient care and resource allocation. This study aimed to apply process mining to explore service utilization and pathways of patients with alcohol use disorders in receiving the community-based Drug and Alcohol Service to establish a baseline for evaluating improvement initiatives.
Methods: Patients' encounters with the Drug and Alcohol Service and their direct care activities (i.
Article Synopsis
- The study investigates the potential link between obstructive sleep apnea (OSA) and cerebral small vessel disease (CSVD), which may contribute to dementia risk, focusing on how aspirin affects these factors in older adults over three years.
- Participants aged 70 and above without major health issues underwent sleep studies, and their brain health was assessed using MRI to measure white matter hyperintensities and silent brain infarctions.
- Findings revealed that OSA was common among participants, but it did not show a relationship with changes in brain imaging measures or retinal vessel sizes, and aspirin use did not significantly alter these outcomes.
Insect guts house a complex community of microbes that affect host physiology, performance and behavior. Gut microbiome research has largely focused on bacteria-host symbioses and paid less attention to other taxa, such as yeasts. We found that axenic Drosophila melanogaster (reared free of microbes) develops from egg to adult more slowly (ca.
View Article and Find Full Text PDFBackground: There are no approved pharmacotherapies for methamphetamine use disorder. Two preliminary phase 2 randomised controlled trials have found mirtazapine, a tetracyclic antidepressant, to be effective in reducing methamphetamine use. The proposed Tina Trial is the first phase 3 placebo-controlled randomised trial to examine the effectiveness and safety of mirtazapine as an outpatient pharmacotherapy for methamphetamine use disorder.
View Article and Find Full Text PDF