Application of various antioxidants in the treatment of influenza.

We determined the effect of the antioxidants superoxide dismutase, desferrioxamine and allopurinol on the survival of male CBA mice infected intranasally with 2-5 LD50 lung influenza virus A/Aichi/2/68. Survival for at least 20 days was observed for 45% of the mice that received 1000 U/day superoxide dismutase prepared from red blood cells on days 5, 6, 7 and 8 after infection, and 75% survival was observed for mice that received the same dose on days 4, 5, 6, 7 and 8. Desferrioxamine, 25 mg/kg per day and 100 mg/kg per day injected subcutaneously, resulted in survival rates of 5 and 0%, respectively, compared to 10% survival observed for saline-injected controls.

[Pathogenesis of severe influenza].

The paper analyzes the contribution of active oxygen radicals whose formation was observed in the inflammatory foci, as well as in generalized influenza infection. There is a correlation between the inactivation of protease inhibitors (alpha-1-antitrypsin) and the increase in the efficacy of virus protein proteolysis, in particular hemagglutinin and hence the acceleration of the infection activation of viral particles. The proteolytic provision of infection viral particle activation occurs due to cell membrane lipid peroxidation, by impairing their barrier function, this is an important condition for the generalization of infection and development of endemic processes.

[Current approaches to the treatment of severe influenza].

The complex pathogenetic therapy of severe (complicated) forms of influenza infection is proposed. The drugs with antioxidant, antiprotease or immunomodulating activities are used for the purpose. The clinical character of infection or stage of pathologic process are considered for appropriate drug application.

[Lipid peroxidation in experimental glaucoma and the possibilities for its correction (preliminary report)].

Lipid peroxidation products and intraocular pressure were measured in 10 rabbits with adrenalin-induced glaucoma, and the possibility of correcting these parameters with a bioantioxidant was tested. Intraocular pressure and levels of lipid peroxidation products in rabbit blood sera were found to grow in the course of adrenalin injections. Intraocular pressure significantly reduced and lipid peroxidation normalized after subconjunctival administration of a bioantioxidant.