Publications by authors named "B G Pozzi"
Unlabelled: Trypanosomes have different ways of communicating with each other. While communication via quorum sensing, or by the release and uptake of extracellular vesicles, is widespread in nature, the phenomenon of flagellar fusion has only been observed in . We showed previously that a small proportion of procyclic culture forms (corresponding to insect midgut forms) can fuse their flagella and exchange cytosolic and membrane proteins.
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- Identifying cognitive impairment in Parkinson's disease is complicated due to varied symptoms and incomplete criteria for diagnosis, with existing screening tools (MMSE and MoCA) lacking a unified approach.
- The study analyzed data from 1,780 Parkinson's patients to establish effective cutoffs for MMSE and MoCA scores across different cognitive stages (normal, mild impairment, dementia).
- A new decision tree model was created, suggesting specific MMSE and MoCA scores to accurately diagnose dementia and mild cognitive impairment, improving diagnostic precision and efficiency for clinicians.
Article Synopsis
- A subset of circular RNAs (circRNAs) and linear RNAs can block microRNA activity, with some RNAs leading to microRNA degradation via a process called Target RNA-Directed MicroRNA Degradation (TDMD).
- In this study, researchers explored how the shape (circular vs. linear) of RNA targets impacts TDMD, finding that the circular RNA Cdr1as protects the microRNA miR-7, while an artificial linear version promotes its degradation.
- The findings suggest that RNA circularity significantly affects TDMD dynamics, influencing the stability and activity of specific microRNAs beyond just their nucleotide sequences.
A key distinguishing factor between mild cognitive impairment (MCI) and dementia in Parkinson's disease (PD) lies in the notable decrease in functioning due to cognitive impairment. The Parkinson's Disease-Cognitive Functional Rating Scale (PD-CRFS) was developed to assess functional limitations caused by cognitive impairment, while reducing the influence of motor impairment. The aim of this multicenter study was to (i) validate the Italian version of the PD-CFRS in PD, (ii) determine optimal cut-off scores for detecting MCI and dementia in PD, (iii) compare its performances with the most established functional assessment tool (IADL).
View Article and Find Full Text PDFInterdigitating dendritic cell sarcoma is a very rare entity in the spectrum of histiocytic and dendritic cell neoplasms that mostly occurs in lymph nodes, generally presenting as solitary lymphadenopathy, but may affect every organ. Among extra nodal sites, cutaneous interdigitating dendritic cell sarcoma is exceedingly rare; to date, only 9 cases have been described in English literature. The mean age at diagnosis was 60 years, with a male-female ratio of 1,5 to 1; clinically, two different modalities of skin presentation have been reported: solitary, represented by a single red-brownish nodular lesion, or diffuse, characterized by multiple nodular lesions in one or more body districts.
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