Publications by authors named "B G Poulsen"
The surge of antimicrobial resistance threatens efficacy of current antibiotics, particularly against Pseudomonas aeruginosa, a highly resistant gram-negative pathogen. The asymmetric outer membrane (OM) of P. aeruginosa combined with its array of efflux pumps provide a barrier to xenobiotic accumulation, thus making antibiotic discovery challenging.
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- - Genetic enhancement of feed efficiency in dairy cows can lead to better economic sustainability and environmental benefits, but reliable data covering entire lactation periods is scarce.
- - This study analyzed data from a research herd of Holstein, Jersey, and Red Dairy Cattle cows, using a multi-variate model to estimate genetic residual feed intake (gRFI) and found moderate heritability and genetic correlations for gRFI across lactation stages.
- - Improving gRFI by one standard deviation could increase net profit per cow-year by 2-3%, with minimal effects on overall production and body management, highlighting the potential of incorporating energy balance into gRFI assessments.
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- The European flat oyster, a vital part of marine ecosystems and a key economic resource, has seen its habitats drastically decline, leading to functional extinction.
- Recent studies compiled data from 1524 to 2022 to reveal past locations and extents of flat oyster fisheries and reefs, highlighting where these ecosystems once thrived.
- These datasets aim to support flat oyster restoration efforts and improve adaptive management strategies while helping recover overlooked histories of ocean ecosystem changes caused by human activities.
Cultivations of Chinese Hamster Ovary (CHO) cells in a perfusion setup were conducted in the presence of super physiological concentrations of L-Arginine to investigate the impact on transmission through the perfusion filter for production of a recombinant domain antibody. Our study revealed that the presence of L-Arginine within the range of 30-50 mM had a positive impact on transmission. However, the higher concentrations were found to have a negative correlation with cell viability, and an optimal concentration of approximately 40 mM was identified.
View Article and Find Full Text PDFThe surge of antimicrobial resistance threatens efficacy of current antibiotics, particularly against , a highly resistant gram-negative pathogen. The asymmetric outer membrane (OM) of combined with its array of efflux pumps provide a barrier to xenobiotic accumulation, thus making antibiotic discovery challenging. We adapted PROSPECT , a target-based, whole-cell screening strategy, to discover small molecule probes that kill mutants depleted for essential proteins localized at the OM.
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