Publications by authors named "B G Koot"
Metabolic dysfunction-associated steatotic liver disease (MASLD) is now the most prevalent chronic liver disease in children in industrialized countries mainly due to the rise in obesity and overweight. Besides risk of progressive liver damage, MASLD also carries an increased risk of extra-hepatic morbidity, most importantly type 2 diabetes mellitus and cardiovascular disease. Important challenges remain in the prevention, detection, and treatment of this prevalent disorder.
View Article and Find Full Text PDFEchinococcus granulosus larvae can cause cystic echinococcosis (CE, also known as hydatid disease) in humans. The latent phase of hydatid disease lasts for years as a result of the slow growth of the cysts, which only become symptomatic when they are large. Therefore, CE is seldomly seen in very young children.
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- The study investigates the effects of oral vancomycin on inflammatory bowel disease (IBD) in patients with primary sclerosing cholangitis (PSC) using data from the Paediatric PSC Consortium.
- A retrospective cohort of 113 PSC-IBD patients was analyzed, comparing 70 treated with vancomycin to 210 untreated ones, focusing on clinical remission after one year.
- Results show vancomycin significantly improves odds of both clinical and endoscopic remission, highlighting the need for further randomized controlled trials to confirm these findings and assess safety and dosing.
Article Synopsis
- - Volanesorsen is an RNA therapy that has shown effectiveness in reducing triglyceride (TG) levels in a 13-year-old girl with lipoprotein lipase (LPL) deficiency, a rare disorder that can lead to severe complications like pancreatitis.
- - The study observed that after starting weekly injections of Volanesorsen, TG levels dropped significantly, with no hospitalizations for pancreatitis in the first 14 months, unlike the patient's previous 21 admissions over a similar timeframe.
- - The treatment was well-tolerated, highlighting an improved quality of life for both the patient and her family, and suggesting the need for broader access to Volanesorsen for pediatric patients with LPL deficiency.
Noninvasive scores are poorly predictive of histological fibrosis in paediatric fatty liver disease.
J Pediatr Gastroenterol Nutr
January 2024
Objectives: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children. Roughly a quarter of paediatric patients with NAFLD develop nonalcoholic steatohepatitis and fibrosis. Here, we evaluated the diagnostic accuracy of previously published noninvasive fibrosis scores to predict liver fibrosis in a large European cohort of paediatric patients with NAFLD.
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