Publications by authors named "B G Khodzhakuliev"

The antiarrhythmic effects of allapinine were studied in 57 patients with chronic circulatory failure (CCF) and cardiac arrhythmias by employing 48-hour Holter monitoring. Allapinine was found to suppress premature ventricular contraction, group premature ventricular contraction and 'runs' of ventricular tachycardia by 82.5, 88.

View Article and Find Full Text PDF

Ventricular arrhythmias were analysed in 38 patients with Stages I-IIB heart failure from 24-hour Holter monitoring data obtained before and after digoxin therapy by comparing with the concentrations of catecholamines. There was a direct relationship between the plasma levels of epinephrine and norepinephrine and the severity of ventricular arrhythmias, as well as between the changes in cumulative catecholamine levels and ventricular arrhythmias during digoxin therapy. Virtually in all cases, the antiarrhythmic effect of the drug was accompanied by lower plasma catecholamine concentrations whereas the levels of norepinephrine and epinephrine remained nearly unchanged or increased with the tentatively arrhythmogenic action.

View Article and Find Full Text PDF

Anti-arrhytmic activity of cordarone was studied in 68 patients with circulatory failure (CF) and heart rhythm disorders with the aid of the 48-hour monitoring of the ECG. Cordarone was administered after the maintenance therapy with digoxin (the mean concentration of digoxin in the plasma 1.38 +/- 0.

View Article and Find Full Text PDF

To specify a possible role played by rhythm disorders in the development of dilated cardiomyopathy (DCM), 9 patients showing permanent sinus and/or supraventricular tachycardia (since birth or within the first 5 years of life) coupled with ventricular rhythm disorders and 11 patients with an assumed infectious disease onset were examined. It has been established that in supraventricular tachycardia, sinus tachycardia included, patients of the child and juvenile age may develop dysfunction of the left ventricle followed by its dilatation which manifests clinically by DCM. The use of antiarrhythmic (cordarone) in such cases may lead to diminution and even to normalization of the heart size and to amelioration of the hemodynamic parameters.

View Article and Find Full Text PDF