Publications by authors named "B G Hannon"
Background: Novel systemic anticancer therapies (SACT) in the form of targeted and immunotherapies are increasingly replacing traditional chemotherapy. Little is known about the impact of novel SACT on healthcare resource utilization (HCRU) at the end of life.
Methodology: A retrospective review of patients attending a tertiary cancer center in Toronto, Canada, with advanced solid or hematological malignancies who died in 2019.
Article Synopsis
- Pancreatic cancer is a challenging disease with a poor outlook and significant symptoms, requiring a collaborative approach in healthcare and research for better patient outcomes.
- The Canadian National Pancreas Conference (NPC) took place in November 2023, bringing together healthcare providers and researchers to focus on enhancing the prognosis and quality of life for pancreatic cancer patients.
- The conference covered various topics, including diagnosis, palliative care, and current management strategies, with reviews of the sessions offered in relation to existing research.
Article Synopsis
- - The opioid overdose epidemic is worsening due to the prevalence of fentanyl and its analogues in illicit drugs, prompting the need for better treatment options.
- - This study focuses on the isolation and efficacy of two families of monoclonal antibodies (mAbs) designed to target fentanyl and carfentanil, revealing that humanizing these mAbs reduced their effectiveness.
- - Structural analysis identified a key residue, Tyr36, in murine mAbs that is vital for binding to fentanyl and carfentanil, highlighting the significance of structural insights in engineering mAbs for opioid treatment.
Background: Estimating prognosis can be a barrier to timely palliative care involvement. The modified Hospitalized-patient One-year Mortality Risk (mHOMR) score uses hospital admission data to calculate the risk of death within 12 months and may be a useful tool to trigger a referral to palliative care.
Methods: The mHOMR tool was retrospectively applied to consecutive acute admissions to a quaternary cancer center in Toronto, Canada from March 1 to May 31, 2018.