Triiodothyronine (T3) increases the expression of the amphiregulin (AREG) oncogene by activating extranuclear pathways in MCF-7 breast cancer cells.

Objective: Considering that the αvβ3 integrin plays an important role in tumor metastasis, this study investigated the involvement of these pathways in mediating the triiodothyronine (T3) effects on amphiregulin () expression.

Materials And Methods: We treated MCF-7 cells with T3 (10 nM) for 1 hour in the presence or absence of inhibitors for αvβ3 integrin (RGD peptide), MAPK (PD98059), PI3K (LY294002), and protein synthesis (cycloheximide [CHX]). A control group (C) received no T3 or inhibitors.

Spirituality-Based Intervention in Hypertension: EFfects on Blood PrEssure and EndotheliaL Function-FEEL Trial Results.

Background: Emerging evidence suggests that spirituality improves patient outcomes, however, this has undergone only limited evaluation in randomized trials. Hypertension is a major cause of cardiovascular morbidity and mortality worldwide.

Objectives: To evaluate whether a spirituality-based intervention, compared to a control group, can reduce blood pressure (BP) and improve endothelial function after 12 weeks in patients with mild or moderate hypertension (HTN).

Selective Serotonin Reuptake Inhibitors: Antimicrobial Activity Against ESKAPEE Bacteria and Mechanisms of Action.

Multidrug-resistant bacteria cause over 700,000 deaths annually, a figure projected to reach 10 million by 2050. Among these bacteria, the ESKAPEE group is notable for its multiple resistance mechanisms. Given the high costs of developing new antimicrobials and the rapid emergence of resistance, drug repositioning offers a promising alternative.

Effect modification in settings with "truncation by death".

Epidemiologic studies recruiting individuals with higher-than-population-average mortality can be affected by "truncation by death", whereby the outcome of interest (e.g. quality of life) is considered not to be defined for individuals who die before the end of follow-up.

Adaptation to Climate Change in Viticulture: The Role of Varietal Selection-A Review.

Viticulture faces unprecedented challenges due to the rapidly changing climate, particularly in regions like the Mediterranean Basin. Consequently, climate change adaptation strategies are crucial in viticulture, with short-term strategies being widely used despite increasing concerns about their sustainability, and long-term strategies considered promising, though costly. A promising but understudied strategy is varietal selection, as grapevines exhibit vast intervarietal diversity with untapped potential for climate-resilient varieties.