2024 Scholars' Research Symposium Abstract: Effect of COVID-19 Pandemic on Routine Pediatric Vaccination Rates in 7 Upper Midwestern States.

Introduction: The COVID-19 pandemic stressed healthcare systems by increasing patient loads and creating shortages of both staffing and medical supplies. As a result, the process of administering routine pediatric vaccinations was affected. Multiple studies have reported ongoing decreases in vaccination opportunities.

missense-perturbation of regulatory element footprints disrupts serotonergic forebrain axon arborization.

Pathogenic coding mutations are prevalent in human neuronal transcription factors (TFs) but how they disrupt development is poorly understood. Lmx1b is a master transcriptional regulator of postmitotic neurons that give rise to mature serotonin (5-HT) neurons; over two hundred pathogenic heterozygous mutations have been discovered in human yet their impact on brain development has not been investigated. Here, we developed mouse models with different DNA-binding missense mutations.

A comparison and calibration of integer and fractional-order models of COVID-19 with stratified public response.

The spread of SARS-CoV-2 in the Canadian province of Ontario has resulted in millions of infections and tens of thousands of deaths to date. Correspondingly, the implementation of modeling to inform public health policies has proven to be exceptionally important. In this work, we expand a previous model of the spread of SARS-CoV-2 in Ontario, "Modeling the impact of a public response on the COVID-19 pandemic in Ontario, " to include the discretized, Caputo fractional derivative in the susceptible compartment.

Cobalt compensator-based IMRT device: A treatment planning study of head and neck cases.

Purpose: Our goal is to develop a novel cobalt-compensator-based IMRT device for low- and middle-income countries that is reliable and cost-effective while delivering treatment plans of equal quality to those from linac-MLC devices. The present study examines the quality of treatment plans using this device.

Methods: A commercial treatment planning system (TPS; RayStation v.

Systemic Treatment Patterns and Outcomes in Patients With EGFR Mutated Non-small Cell Lung Cancer and Leptomeningeal Disease.

Introduction: Leptomeningeal (LM) disease occurs in 9% to 10% of EGFR mutated non-small cell lung cancer (NSCLC) cases. The natural history and optimal systemic treatment strategies for this disease are not well-characterized, particularly in the era of osimertinib.

Materials And Methods: We identified 54 patients with EGFR mutated NSCLC and LM disease diagnosed between January 3, 2000 to March 31, 2020 and treated at an academic oncology practice in Seattle, Washington.