Publications by authors named "B G Chousterman"
In patients with acute brain injury (ABI), optimizing cerebral perfusion parameters relies on multimodal monitoring. This include data from systemic monitoring-mean arterial pressure (MAP), arterial carbon dioxide tension (PaCO), arterial oxygen saturation (SaO), hemoglobin levels (Hb), and temperature-as well as neurological monitoring-intracranial pressure (ICP), cerebral perfusion pressure (CPP), and transcranial Doppler (TCD) velocities. We hypothesized that these parameters alone were not sufficient to assess the risk of cerebral ischemia.
View Article and Find Full Text PDFBackground: Recent findings suggest that β3-adrenergic receptors (β3-AR) could play a role in the hemodynamic regulation, but their function in septic shock remains unclear. This study investigates the modulation of β3-AR in an experimental murine model of resuscitated septic shock on in vivo hemodynamic, ex vivo vasoreactivity, inflammation and survival.
Method: Wild-type mice were used, undergoing cecal ligation and puncture (CLP) to induce septic shock, with SHAM as controls.
Background And Objectives: Diagnosing ventriculostomy-related infection (VRI), a common complication after external ventricular drainage (EVD), is challenging and often associated with delayed initiation of antibiotic therapy. We aimed to develop a stewardship score to help in the decision of antibiotic therapy initiation when VRI is suspected.
Methods: This retrospective, single-center cohort study included patients admitted to the intensive care unit after EVD placement who were suspected of having healthcare-associated ventriculitis and/or meningitis between January 1, 2012, and August 31, 2022.
Early mobilization in patients with aneurysmal subarachnoid haemorrhage may im-prove functional status and reduce cerebral vasospasm rate: a systematic review with meta-analysis.
J Rehabil Med
October 2024
Article Synopsis
- The study aimed to assess how safe and effective early mobilization is for patients who have experienced an aneurysmal subarachnoid hemorrhage.
- It included a systematic review and meta-analysis of 16 studies with 1,757 patients, revealing that early mobilization improved patient outcomes, as indicated by better mRS scores at discharge and three months later.
- The findings suggest that while early mobilization is associated with a lower rate of cerebral vasospasm, some adverse events did occur, highlighting the need for more controlled trials to refine mobilization strategies and validate these results.
Article Synopsis
- The study investigates the experiences of ICU healthcare professionals regarding controlled donation after circulatory death (cDCD), amid ethical concerns between end-of-life care and organ donation.
- Conducted in 32 ICUs in France, the study surveyed 206 physicians and nurses after the deaths of patients considered potential cDCD donors, measuring their anxiety levels and feelings of tension related to the donation process.
- Results show that cDCD does not significantly increase anxiety for healthcare professionals compared to regular end-of-life situations, with a general positive perception of cDCD among them, suggesting a need for better support in balancing life support decisions and organ donation.