Publications by authors named "B G CROSS"
We recently discovered a novel N-aryl tetracyclic dicarboximide MM0299 () with robust activity against glioma stem-like cells that potently and selectively inhibits lanosterol synthase leading to the accumulation of the toxic shunt metabolite 24(),25-epoxycholesterol. Herein, we delineate a systematic and comprehensive SAR study that explores the structural space surrounding the N-aryl tetracyclic dicarboximide scaffold. A series of 100 analogs were synthesized and evaluated for activity against the murine glioma stem-like cell line Mut6 and for metabolic stability in mouse liver S9 fractions.
View Article and Find Full Text PDFBackground: The Keap1-Nrf2 pathway serves as a central regulator that mediates transcriptional responses to xenobiotic and oxidative stimuli. Recent studies have shown that Keap1 and Nrf2 can regulate transcripts beyond antioxidant and detoxifying genes, yet the underlying mechanisms remain unclear. Our research has uncovered that Drosophila Keap1 (dKeap1) and Nrf2 (CncC) proteins can control high-order chromatin structure, including heterochromatin.
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- * Individual responses to these medications vary significantly, which can lead to serious complications like thrombosis or bleeding, and recognizing factors contributing to this variability is crucial for patient safety.
- * Genetic markers like VKORC1 and CYP2C9 can help tailor warfarin dosing, but more research is needed on other anticoagulants and factors like body weight to improve treatment outcomes for at-risk patients.
Article Synopsis
- This study looked at how mental health issues like depression and anxiety affect people with Parkinson's disease and how these issues relate to their overall health and well-being.
- Researchers examined many studies to find out if having these mental health problems makes Parkinson's symptoms worse, which can include things like memory problems and falling.
- They found a lot of evidence showing that problems like psychosis are linked to worse outcomes in Parkinson's patients, indicating that mental health is really important for their overall condition.
Men with antisocial personality disorder (ASPD) with or without psychopathy (+/-P) are responsible for most violent crime in society. Development of effective treatments is hindered by poor understanding of the neurochemical underpinnings of the condition. Men with ASPD with and without psychopathy demonstrate impulsive decision-making, associated with striatal abnormalities in functional neuroimaging studies.
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