Family and Home Environment Predictors of Children's 24-Hour Movement Guideline Adherence: A Mixed-Methods Study.

During summer, children may meet fewer 24 hours Movement Guidelines (24 hr-MGs) [moderate-vigorous physical activity (PA): ≥60 minutes/day, screen time: ≤2 hours/day, sleep: 9-11 hours/day) compared with the school year. Structured environments within community settings (, summer programs) support guideline adherence. Information about the relationship between structured home environments and 24 hr-MGs is needed.

Developing Topics.

Background: Improving modifiable risk factors, like diet quality, can protect against Alzheimer's disease (AD). The association between diet and cognition in midlife as a function of APOE-e4 genotype, a strong risk factor for AD, remains unknown. Therefore, this study examined the relationship between dietary intake and executive function (EF) in middle-aged sedentary women with a family history of AD (FH+), and if the association was moderated by APOE-e4 carrier status.

Developing Topics.

Background: In APOE ε4 allele carriers at increased risk for Alzheimer's disease (AD), midlife (age 40-65 years) is a critical window when amyloid-β (Aβ) pathology could progress without overt cognitive decline, but AD-related biomarkers may be present. Blood measures of phosphorylated tau at Thr217 (p-tau217) indicate aggregated Aβ pathology in the preclinical stage of AD, whereas ApoE protein levels are associated with the clearance of Aβ. C-reactive protein (CRP) and serum amyloid A (SAA) are acute phase reactants within the inflammatory pathway, but SAA is also related to ApoE levels and Aβ clearance.

Developing Topics.

Background: ApolipoproteinE ε4 carriers (ε4+) have a heightened risk for Alzheimer's disease (AD) and experience accelerated hippocampal volume (HV) loss during older adulthood, which tends to precede cognitive decline. Exercise interventions can increase HV in sedentary older adults, however it's currently unknown how exercise affects HV in sedentary middle-aged adults and if ε4 carrier status moderates this relationship.

Methods: A subset of 44 adults from an ongoing randomized controlled clinical trial (NIH/NIA: R01AG058919) completed baseline (pre), 6-month (mid), and 12-month (post) testing during a one-year exercise intervention (n = 29, 52% ε4+, 5 males, Age = 55.

Rapid climate action is needed: comparing heat vs. COVID-19-related mortality.

The impacts of climate change on human health are often underestimated or perceived to be in a distant future. Here, we present the projected impacts of climate change in the context of COVID-19, a recent human health catastrophe. We compared projected heat mortality with COVID-19 deaths in 38 cities worldwide and found that in half of these cities, heat-related deaths could exceed annual COVID-19 deaths in less than ten years (at + 3.