Publications by authors named "B Frauchiger"
Background: Respiratory tract infections (RTIs) drive lung function decline in children with cystic fibrosis (CF). While the respiratory microbiota is clearly associated with RTI pathogenesis in infants without CF, data on infants with CF is scarce. We compared nasal microbiota development between infants with CF and controls and assessed associations between early-life nasal microbiota, RTIs, and antibiotic treatment in infants with CF.
View Article and Find Full Text PDFBackground: Non-invasive and sensitive clinical endpoints are needed to monitor onset and progression of early lung disease in children with cystic fibrosis (CF). We compared lung clearance index (LCI), FEV, functional and structural lung magnetic resonance imaging (MRI) outcomes in Swiss children with CF diagnosed following newborn screening.
Methods: Lung function (LCI, FEV) and unsedated functional and structural lung MRI was performed in 79 clinically stable children with CF (3 - 8 years) and 75 age-matched healthy controls.
Background: Multiple-breath washout (MBW) is a sensitive method for assessing lung volumes and ventilation inhomogeneity in infants, but remains prone to artefacts (e.g., sighs).
View Article and Find Full Text PDFThrombin Generation Is Associated with Venous Thromboembolism Recurrence, but Not with Major Bleeding and Death in the Elderly: A Prospective Multicenter Cohort Study.
J Clin Med
September 2023
Article Synopsis
- The study investigates the link between thrombin generation and the recurrence of venous thromboembolism (VTE), major bleeding, and mortality in elderly patients (aged 65 and older) with acute VTE.
- Researchers followed 551 patients for 2 years, assessing thrombin generation one year after initial VTE treatment, with the primary focus on outcomes like VTE recurrence, major bleeding, and mortality.
- The findings indicate that while thrombin generation can help predict VTE recurrence in non-anticoagulated elderly patients, it does not correlate with major bleeding or mortality, suggesting its potential use in identifying high-risk individuals for VTE recurrence.
Background: Nitrogen multiple breath washout (N2MBW) is a lung function test increasingly used in small airway diseases. Quality criteria have not yet been globally implemented and time-consuming retrospective overreading is necessary. Little data has been published on children with recurrent wheeze or asthma from multicentered studies.
View Article and Find Full Text PDF