Publications by authors named "B Franklin Pugh"
Article Synopsis
- * Accurately mapping torsion in chromatin is difficult due to the challenge of establishing a zero-torsion baseline signal influenced by chromatin accessibility.
- * A new high-resolution method using trimethylpsoralen (TMP) allows researchers to measure torsional stress while maintaining chromatin state, revealing insights about transcription and its effects on genome architecture.
The SWR1 chromatin remodeling complex is recruited to +1 nucleosomes downstream of transcription start sites of eukaryotic promoters, where it exchanges histone H2A for the specialized variant H2A.Z. Here, we use cryoelectron microscopy (cryo-EM) to resolve the structural basis of the SWR1 interaction with free DNA, revealing a distinct open conformation of the Swr1 ATPase that enables sliding from accessible DNA to nucleosomes.
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- Sexual violence is a widespread issue that has significant negative effects on victims, which can be influenced by whether individuals consider their experience as rape.
- This study examined rape acknowledgment among a diverse sample, finding that 44% acknowledged their rape, while 20% were uncertain, and 33% did not recognize their experience as rape.
- Results showed that gender identity plays a crucial role in acknowledgment, with sexual minority transgender/nonbinary individuals being the most likely to acknowledge their rape compared to other groups, highlighting a need for further research in this area.
Disturbance in neuroendocrine signaling has been consistently documented in multiple sclerosis (MS), a chronic autoimmune disorder of the central nervous system (CNS) representing the main cause of non-traumatic brain injury among young adults. In fact, MS patients display altered hormonal levels and psychiatric symptoms along with the pathologic hallmarks of the disease, which include demyelination, neuroinflammation and axonal injury. In addition, we have recently shown that extensive transcriptional changes take place in the hypothalamus of mice upon the MS model experimental autoimmune encephalomyelitis (EAE).
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