Publications by authors named "B Franceschini"
Article Synopsis
- Systemic inflammation plays a crucial role in intrahepatic cholangiocarcinoma (iCCA), and this study investigates the prognostic importance of inflammatory indexes like the neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR).
- A total of 101 iCCA patients were analyzed, revealing that higher NLR and lower LMR correlate with worse survival outcomes; those with high-risk profiles had significantly lower 5-year overall survival rates compared to low-risk patients.
- Flow cytometry results showed distinct immune cell profiles, with high-risk patients having more CD4+ T-cells and fewer CD8+ T-cells, suggesting inflammatory indexes can serve as indicators for tumor microenvironment and prognosis
Background And Aim: VETC (vessel that encapsulate tumor cluster) is a peculiar vascular phenotype observed in hepatocellular carcinoma (HCC), associated with distant metastases and poor outcome. VETC has been linked to the Tie2/Ang2 axis and is characterized by lymphocytes poor (cold) tumor microenvironment (TME). In this setting the role of Tumor Associated Macrophages (TAMs) has never been explored.
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- - Tumor-associated macrophages (TAMs) play a crucial role in the tumor microenvironment, with smaller TAMs (S-TAMs) linked to better prognosis in colorectal liver metastasis compared to larger TAMs (L-TAMs).
- - Research using multiparametric flow cytometry and metabolomics identified that L-TAMs show a strong association with riboflavin, which affects the enzyme lysine-specific demethylase 1A (LSD1) and plays a role in TAM morphology.
- - The study suggests that targeting the riboflavin-LSD1 relationship could reprogram TAM subtypes, offering new strategies for anti-tumor therapies.
Liver cancer represents the fourth leading cause of cancer-associated death worldwide. The heterogeneity of its tumor microenvironment (TME) is a major contributing factor of metastasis, relapse, and drug resistance. Regrettably, late diagnosis makes most liver cancer patients ineligible for surgery, and the frequent failure of non-surgical therapeutic options orientates clinical research to the investigation of new drugs.
View Article and Find Full Text PDFBackground & Aims: Cholangiocarcinoma (CCA) is a primary liver tumour characterised by a poor prognosis and limited therapeutic options. Available 3D human CCA models fail to faithfully recapitulate the tumour niche. We aimed to develop an innovative patient-specific CCA-on-chip platform.
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