Publications by authors named "B Fortin"
Diet is a robust entrainment cue that regulates diurnal rhythms of the gut microbiome. We and others have shown that disruption of the circadian clock drives the progression of colorectal cancer (CRC). While certain bacterial species have been suggested to play driver roles in CRC, it is unknown whether the intestinal clock impinges on the microbiome to accelerate CRC pathogenesis.
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- - The circadian clock plays a crucial role in regulating the immune system and is important for both disease defense and cancer detection.
- - Research using single-cell RNA sequencing reveals that certain immune cells, particularly PD-L1-expressing myeloid-derived suppressor cells (MDSCs), oscillate in numbers based on the time of day and suppress the activity of CD8 T cells.
- - Timing the administration of anti-PD-L1 treatment to coincide with the peak levels of MDSCs enhances its effectiveness, highlighting the importance of circadian rhythms in cancer immunotherapy.
Background: Patients with left ventricular assist devices (LVADs) require interruption of warfarin for invasive procedures, but parenteral bridging is associated with many complications. Four-factor prothrombin complex concentrate (4F-PCC) can temporarily restore hemostasis in patients undergoing anticoagulation with warfarin.
Objectives: This pilot study evaluated the strategy of using variable-dose 4F-PCC to immediately and temporarily reverse warfarin before invasive procedures without holding warfarin in patients with LVADs.
Circadian Clock Dysregulation and Prostate Cancer: A Molecular and Clinical Overview.
Clin Med Insights Oncol
November 2023
Circadian clock dysregulation has been implicated in various types of cancer and represents an area of growing research. However, the role of the circadian clock in prostate cancer has been relatively unexplored. This literature review will highlight the potential role of circadian clock dysregulation in prostate cancer by examining molecular, epidemiologic, and clinical data.
View Article and Find Full Text PDFObjectives: Delays in treatment time intervals have been associated with overall survival in oral cavity squamous cell carcinoma (OCSCC). The aim of this study was to identify bottlenecks leading to prolonged treatment intervals.
Material And Methods: A retrospective analysis was conducted using a cohort of OCSCC patients who underwent surgery and adjuvant radiation therapy.