Publications by authors named "B Fornwalt"

Article Synopsis
  • A study developed a deep learning model called StrainNet that analyzes heart displacement and strain using cine MRI data and DENSE measurements.
  • It involved training and testing the model on data gathered from a diverse group of patients with heart diseases and healthy individuals over several years, focusing on the model's accuracy in predicting myocardial movements.
  • The results indicated that StrainNet performed better than traditional feature tracking methods, showing strong agreement with DENSE measurements for both global and segmental strain analysis.
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Background: Several large trials have employed age or clinical features to select patients for atrial fibrillation (AF) screening to reduce strokes. We hypothesized that a machine learning (ML) model trained to predict AF risk from 12‑lead electrocardiogram (ECG) would be more efficient than criteria based on clinical variables in indicating a population for AF screening to potentially prevent AF-related stroke.

Methods: We retrospectively included all patients with clinical encounters in Geisinger without a prior history of AF.

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Objective: Children with single-sided deafness often receive inconsistent clinical recommendations because there is currently no clear best practice in paediatric single-sided deafness. This systematic review of the literature aimed to compare commonly used treatments and attempted to support the use of a particular treatment modality.

Method: This was a comprehensive literature review from 1 January 2000 to 22 February 2022; the study compared the outcomes of bone conduction devices and cochlear implantation in paediatric patients with single-sided deafness.

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Article Synopsis
  • Accurate classification of variants' pathogenicity is essential for both research and clinical applications, showing significant connections between rare variants and specific health traits in three monogenic diseases.* -
  • Analysis of data from three large studies reveals that effect sizes linked to these health traits can effectively differentiate between pathogenic and non-pathogenic variants, with strong statistical significance (P < 0.001).* -
  • The research suggests that using these quantitative endophenotypes can identify up to 35% of rare variants of uncertain significance as potentially pathogenic, thereby enhancing our understanding of disease susceptibility.*
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