Efficient scaling of large language models with mixture of experts and 3D analog in-memory computing.

Large language models (LLMs), with their remarkable generative capacities, have greatly impacted a range of fields, but they face scalability challenges due to their large parameter counts, which result in high costs for training and inference. The trend of increasing model sizes is exacerbating these challenges, particularly in terms of memory footprint, latency and energy consumption. Here we explore the deployment of 'mixture of experts' (MoEs) networks-networks that use conditional computing to keep computational demands low despite having many parameters-on three-dimensional (3D) non-volatile memory (NVM)-based analog in-memory computing (AIMC) hardware.

Economic development trends in the EU tourism industry. Towards the digitalization process and sustainability.

From an economic viewpoint, tourism is heralded as bringing income to local communities. From an ecological standpoint, tourism poses a threat to environments. Sustainable tourism should leave a minimum negative impact on the places visited and preferably have rather positive impact on society.

Accuracy in Diagnosis of Celiac Disease Without Biopsies in Clinical Practice.

Background & Aims: The guidelines of the European Society of Pediatric Gastroenterology, Hepatology, and Nutrition allow for diagnosis of celiac disease without biopsies in children with symptoms and levels of immunoglobulin A against tissue-transglutaminase (TGA-IgA) 10-fold or more the upper limit of normal (ULN), confirmed by detection of endomysium antibodies (EMA) and positivity for HLA-DQ2/DQ8. We performed a large, international prospective study to validate this approach.

Methods: We collected data from consecutive pediatric patients (18 years or younger) on a gluten-containing diet who tested positive for TGA-IgA from November 2011 through May 2014, seen at 33 pediatric gastroenterology units in 21 countries.

Early allergic sensitizations and their relevance to atopic diseases in children aged 6 years: results of the GINI study.

Background: Only a few studies have analyzed the value of early sensitization in predicting the development of atopic disease. The relevance of low immunoglobulin (Ig) E antibody levels in this respect also remains unclear.

Objective: To investigate the relevance of sensitization in 12-month-old children in the development of atopic disease by the age of 6 years.

Solid food introduction in relation to eczema: results from a four-year prospective birth cohort study.

Objective: To assess the association between the introduction of solid foods in the first 12 months and the occurrence of eczema during the first 4 years of life in a prospective study of newborns.

Study Design: Data were taken from annually administered questionnaires from a large birth cohort (recruited 1995-1998) comprised of an intervention and a nonintervention group. Outcomes were doctor-diagnosed and symptomatic eczema.