Publications by authors named "B Fiedler"

Microneedles (MNs) offer the potential for discrete and painless transdermal drug delivery, yet poor insertion and dosing consistency have hindered their clinical translation. Specifically, hollow MNs are appropriate for the administration of liquid modalities, including insulin, which could prove to be beneficial for patients with type 1 diabetes mellitus. This work aimed to design and manufacture a hollow MN with an improved insertion and delivery profile suitable for insulin administration.

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Background: ChatGPT is rapidly becoming a source of medical knowledge for patients. This study aims to assess the completeness and accuracy of ChatGPT's answers to the most frequently asked patients' questions about shoulder pathology.

Methods: ChatGPT (version 3.

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Article Synopsis
  • Increased commercial spaceflight and space tourism highlight the need to understand the impact of spaceflight on musculoskeletal health, particularly regarding upper extremity injuries, which are the most common in this environment.
  • A literature review revealed that spaceflight leads to decreased bone mineral density, various muscle atrophy patterns, and peripheral nerve issues, such as hand numbness, but the exact causes remain unclear.
  • Although current research offers some insights into maintaining upper extremity health during spaceflight, significant knowledge gaps persist, indicating a need for further investigation into injury risks and preventative measures.
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  • * Researchers sequenced the genomes of two zoantharians, Palythoa mizigama and Palythoa umbrosa, revealing their total genome sizes and identifying a significant number of protein-coding genes with strong completeness.
  • * The study found that certain gene families, particularly those related to toxins and other functions, were conserved and expanded in Palythoa species, while some gene losses seemed to relate to neuronal functions, suggesting adaptations to their dark coral reef cave environment.
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Group 3 innate lymphoid cells (ILC3s) are abundant in the developing or healthy intestine to critically support tissue homeostasis in response to microbial colonization. However, intestinal ILC3s are reduced during chronic infections, colorectal cancer, or inflammatory bowel disease (IBD), and the mechanisms driving these alterations remain poorly understood. Here we employed RNA sequencing of ILC3s from IBD patients and observed a significant upregulation of RIPK3, the central regulator of necroptosis, during intestinal inflammation.

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