Publications by authors named "B Fernandez Infante"
Monoclonal gammopathy of renal significance (MGRS) refers to a group of renal disorders caused by a monoclonal immunoglobulin (MIg), secreted by a non-malignant B-cell clone. Unlike overt multiple myeloma or B-cell proliferation, MGRS does not meet those diagnostic criteria. However, it is associated with significant morbidity, due to severe renal, and sometimes systemic, lesions induced by the MIg.
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- Anderson-Fabry disease (AFD) is a rare genetic disorder that leads to organ damage due to a lack of α-galactosidase A, causing harmful substances to accumulate in tissues, particularly affecting the heart and kidneys.
- * Researchers conducted a study using cardiovascular magnetic resonance (CMR) and T1 mapping to evaluate kidney involvement in 19 AFD patients compared to a control group without kidney disease.
- * The findings indicated a positive correlation between heart and kidney T1 values in AFD patients, and a negative correlation in kidney T1 values between AFD and control patients, suggesting kidney damage from microvascular issues in AFD.
The evaluation of estimated GFR (eGFR) is a pivotal staging step in patients with chronic kidney disease (CKD), and renal ultrasound plays an important role in diagnosis, prognosis and progression of CKD. The interaction between histopathological diagnosis and ultrasound parameters in eGFR determination has not been fully investigated yet. The study examined the results of native kidney biopsies performed in 48 Italian centers between 2012 and 2020.
View Article and Find Full Text PDFThe aging process contributes significantly to the onset of chronic diseases, which are the primary causes of global mortality, morbidity, and healthcare costs. Numerous studies have shown that the removal of senescent cells from tissues extends lifespan and reduces the occurrence of age-related diseases. Consequently, there is growing momentum in the development of drugs targeting these cells.
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- Plasmodium vivax is a major malaria species in Latin America, responsible for 71.5% of cases in 2021, highlighting the need for effective national malaria control programs and innovative genomic surveillance methods.
- A new deep sequencing assay was developed and applied to 230 samples from the Peruvian Amazon, revealing a highly diverse P. vivax population with significant genetic variations and evidence of drug-resistant genes related to potential reintroductions from Brazil.
- The findings support the use of genomic tools to enhance malaria surveillance and inform local control efforts, ultimately contributing to elimination strategies in Peru and potentially across Latin America.