The Histone Deacetylases Hst1 and Rpd3 Integrate De Novo NAD Metabolism with Phosphate Sensing in .

Nicotinamide adenine dinucleotide (NAD) is a critical cofactor essential for various cellular processes. Abnormalities in NAD metabolism have also been associated with a number of metabolic disorders. The regulation and interconnection of NAD metabolic pathways are not yet completely understood.

The histone deacetylases Rpd3 and Hst1 antagonistically regulate de novo NAD metabolism in the budding yeast Saccharomyces cerevisiae.

NAD is a cellular redox cofactor involved in many essential processes. The regulation of NAD metabolism and the signaling networks reciprocally interacting with NAD-producing metabolic pathways are not yet fully understood. The NAD-dependent histone deacetylase (HDAC) Hst1 has been shown to inhibit de novo NAD synthesis by repressing biosynthesis of nicotinic acid (BNA) gene expression.

NAD Metabolism, Metabolic Stress, and Infection.

Nicotinamide adenine dinucleotide (NAD) is an essential metabolite with wide-ranging and significant roles in the cell. Defects in NAD metabolism have been associated with many human disorders; it is therefore an emerging therapeutic target. Moreover, NAD metabolism is perturbed during colonization by a variety of pathogens, either due to the molecular mechanisms employed by these infectious agents or by the host immune response they trigger.

Supported Employment, Participation at Work, and Peer Support: A Qualitative, Participatory Case Study Report of the Geesthacht Model.

For people who have experienced mental health crises or psychosocial disabilities, it is considerably more difficult to receive support to participate in work on an equal basis with others. In the town of Geesthacht, in Northern Germany, an integrative care network was implemented that allows for acute psychiatric treatment as well as participation in work and activities. This paper aims to explore the principles, advantages, and challenges of this innovative project.

First report of Cytauxzoon sp. infection in Germany: organism description and molecular confirmation in a domestic cat.

Cytauxzoonosis is described as an emerging tick-borne disease of domestic and wild felids caused by protozoans of the genus Cytauxzoon. While in the Americas the condition is described as a fatal disease, in Europe, reports on the clinical expression of the infection are scarce. This study describes the first case of Cytauxzoon sp.