Publications by authors named "B Faber"
Article Synopsis
- The study explores the link between hip shape and the risk of hip osteoarthritis and fractures, using data from large cohorts to analyze genetic factors influencing hip shape.
- Researchers identified numerous genetic signals related to hip shape but found no causal effect of hip shape on osteoarthritis, while certain hip shapes were linked to a higher risk of hip fractures.
- The findings suggest that focusing on hip shape might not be an effective strategy for preventing osteoarthritis in older adults, despite its association with hip fractures.
Article Synopsis
- - Cardiovascular risk scoring tools can be effectively used in osteoporosis clinics to assess patients' overall health.
- - However, these tools are not interchangeable, meaning each has its own specific purpose and limitations that should be considered.
- - Proper selection and application of the appropriate scoring tool are essential for accurate risk assessment and management in osteoporosis patients.
Sex differences in the radiographic and symptomatic prevalence of knee and hip osteoarthritis.
Front Endocrinol (Lausanne)
October 2024
Recognising sex differences in disease prevalence can lead to clues as to its pathogenesis, for example the role of hormonal factors and related influences such as body composition, as well as forming the basis for new treatments. However, if different methods are used to define the disorder it can be difficult to explore differences in prevalence, making it necessary to draw on multiple sources of evidence. This narrative review addresses sex differences in the prevalence of knee and hip osteoarthritis, which are the most common forms of large joint osteoarthritis.
View Article and Find Full Text PDFApical Membrane Antigen 1 (AMA1) plays a vital role in the invasion of the host erythrocyte by the malaria parasite, . It is thus an important target for vaccine and anti-malaria therapeutic strategies that block the invasion process. AMA1, present on the surface of the parasite, interacts with RON2, a component of the parasite's rhoptry neck (RON) protein complex, which is transferred to the erythrocyte membrane during invasion.
View Article and Find Full Text PDFAntigen identity, quantity and integrity are key factors to be evaluated as part of consistency testing of tetanus vaccines. Here we have developed a monoclonal antibody sandwich ELISA to measure the relative amount and quality of tetanus toxoid (TTxd) in human and animal tetanus vaccines. The ELISA is highly specific, has good dilutional linearity, and is suitable for detecting TTxd in a range of different products.
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