The association between dietary creatine intake and cancer in U.S. adults: insights from NHANES 2007-2018.

Background: Creatine has anti-inflammatory, antioxidant, and immunomodulatory effects. However, its impact on tumors remains uncertain.

Methods: This study used data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018 to investigate the relationship between dietary creatine intake and cancer in American adults.

A case of relapsed gAChR-positive autoimmune autonomic ganglionopathy treated by plasma exchange and mycophenolate mofetil.

Autoimmune autonomic ganglionopathy (AAG) is a rare and acquired immune-mediated disease that leads to wide autonomic failure, mainly characterized by orthostatic hypotension, gastrointestinal dysfunction, anhidrosis and poorly reactive pupils. This disorder is usually associated with autoantibodies to the ganglionic nicotinic acetylcholine receptor (gAChR-Ab). In this study, we describe a case of a gAChR-Ab-positive AAG patient with two therapeutic stages.

Finding a needle in a haystack: functional screening for novel targets in cancer immunology and immunotherapies.

Genome-wide functional genetic screening has been widely used in the biomedicine field, which makes it possible to find a needle in a haystack at the genetic level. In cancer research, gene mutations are closely related to tumor development, metastasis, and recurrence, and the use of state-of-the-art powerful screening technologies, such as clustered regularly interspaced short palindromic repeat (CRISPR), to search for the most critical genes or coding products provides us with a new possibility to further refine the cancer mapping and provide new possibilities for the treatment of cancer patients. The use of CRISPR screening for the most critical genes or coding products has further refined the cancer atlas and provided new possibilities for the treatment of cancer patients.

An X-Band Class-J GaN MMIC Power Amplifier with Well-Designed In-Band Output Power Flatness.

This paper presents an X-band high-power GaN MMIC power amplifier (PA). To balance efficiency, output power, and saturated power flatness, the load-line theory is employed to analyze and validate the power variation trends within an extended continuous Class B/J (CCBJ) impedance space. Theoretical constant power contours are plotted within this space.

The Role of Polyphenols in Abiotic Stress Tolerance and Their Antioxidant Properties to Scavenge Reactive Oxygen Species and Free Radicals.

Plants have evolved complex mechanisms to cope with diverse abiotic stresses, with the phenylpropanoid pathway playing a central role in stress adaptation. This pathway produces an array of secondary metabolites, particularly polyphenols, which serve multiple functions in plant growth, development, regulating cellular processes, and stress responses. Recent advances in understanding the molecular mechanisms underlying phenylpropanoid metabolism have revealed complex regulatory networks involving MYB transcription factors as master regulators and their interactions with stress signaling pathways.