Publications by authors named "B F M Trazzi"

Cholelithiasis has a major impact on global health and affects an average of 20% of the Western population. The main risk factors are females, age over 40 years, obesity and pregnancy. Most of the time it is asymptomatic, but when there are symptoms, they are generally nonspecific.

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Robust, fault tolerant, and available systems are fundamental for the adoption of Internet of Things (IoT) in critical domains, such as finance, health, and safety. The IoT infrastructure is often used to collect a large amount of data to meet the business demands of Smart Cities, Industry 4.0, and Smart Home, but there is a opportunity to use these data to intrinsically monitor an IoT system in an autonomous way.

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Flavonoids are natural phytochemicals that have therapeutic effects and act in the prevention of several pathologies. These phytochemicals can be found in seeds, grains, tea, coffee, wine, chocolate, cocoa, vegetables and, mainly, in citrus fruits. Neohesperidin, hesperidin and hesperetin are citrus flavonoids from the flavanones subclass that have anti-inflammatory and antioxidant potential.

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In this experimental protocol, the objective was to evaluate the biological behavior of two xenogenic scaffolds in alcohol-induced rats through histomorphometric and Picrosirius Red staining analysis of non-critical defects in the tibia of rats submitted or not to alcohol ingestion at 25% /. Eighty male rats were randomly divided into four groups ( = 20 each): CG/B (water diet + Bio-Oss graft, Geistlich Pharma AG, Wolhusen, Switzerland), CG/O (water diet + OrthoGen graft, Baumer, Mogi Mirim, Brazil), AG/B (25% / alcohol diet + Bio-Oss graft), and AG/O (25% / alcohol diet + OrthoGen graft). After 90 days of liquid diet, the rats were surgically obtained, with a defect in the tibia proximal epiphysis; filled in according to their respective groups; and euthanized at 10, 20, 40 and 60 days.

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Cell-based therapy is a promising treatment to favor tissue healing through less invasive strategies. Mesenchymal stem cells (MSCs) highlighted as potential candidates due to their angiogenic, anti-apoptotic and immunomodulatory properties, in addition to their ability to differentiate into several specialized cell lines. Cells can be carried through a biological delivery system, such as fibrin glue, which acts as a temporary matrix that favors cell-matrix interactions and allows local and paracrine functions of MSCs.

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