Impact of Exposure to a Mixture of Organophosphate Esters on the Adrenal Glands of Sprague Dawley Rats.

There is growing evidence that organophosphate esters (OPEs) can act as endocrine-disrupting chemicals. However, only a few studies have assessed the effects of OPE exposure on one of the most important endocrine glands in the body, the adrenal gland. Our aim was to test the effects of a mixture of OPEs detected in Canadian house dust on adrenal function in Sprague Dawley rats.

The Effects of Bisphenol A and its Analogs on Steroidogenesis in MA-10 Leydig Cells and KGN Granulosa Cells†.

Bisphenols are a family of chemicals used in the manufacture of consumer products containing polycarbonate plastics and epoxy resins. Studies have shown that exposure to bisphenol A (BPA) may disrupt steroidogenesis and induce adverse effects on male and female reproduction, but little is known about BPA replacements. We determined the effects of six bisphenols on the steroidogenic function of MA-10 Leydig cells and KGN granulosa cells by measuring the levels of progesterone and estradiol produced by these cells as well as the expression of transcripts involved in steroid and cholesterol biosynthesis.

Feedbacks Between Estuarine Metabolism and Anthropogenic CO Accelerate Local Rates of Ocean Acidification and Hasten Threshold Exceedances.

Attribution of the ocean acidification (OA) signal in estuarine carbonate system observations is necessary for quantifying the impacts of global anthropogenic emissions on water quality, and informing managers of the efficacy of potential mitigation options. We present an analysis of observational data to characterize dynamics and drivers of seasonal carbonate system variability in two seagrass habitats of Puget Sound, WA, USA, and estimate how carbon accumulations due to anthropogenic emissions interact with these drivers of carbonate chemistry to determine seasonally resolved rates of acidification in these habitats. Three independent simulations of accumulation from 1765 to 2100 were run using two previously published methods and one novel method for estimation.

House dust-derived mixtures of organophosphate esters alter the phenotype, function, transcriptome, and lipidome of KGN human ovarian granulosa cells.

Organophosphate esters (OPEs), used as flame retardants and plasticizers, are present ubiquitously in the environment. Previous studies suggest that exposure to OPEs is detrimental to female fertility in humans. However, no experimental information is available on the effects of OPE mixtures on ovarian granulosa cells, which play essential roles in female reproduction.