Publications by authors named "B Eisenberg"
Article Synopsis
- - The study focused on gastrointestinal stromal tumors (GISTs), which often have mutations in the KIT or PDGFRA proteins, making them targets for the drug imatinib mesylate.
- - Analysis of tumors from 127 patients revealed that 88.2% had KIT mutations (mostly in exons 9 and 11), with those having exon 11 mutations showing an 83.5% response rate to imatinib, while those with exon 9 mutations or no detectable mutations had lower response rates.
- - The findings highlight that the presence and type of mutations in KIT or PDGFRA are significant indicators of how well patients with GISTs might respond to imatinib treatment.
Generalized anxiety disorder (GAD) in children and adolescents is associated with substantial morbidity and increases the risk of future psychopathology. However, relatively few psychopharmacologic studies have examined treatments for GAD in pediatric populations, especially in prepubertal youth. Children and adolescents aged 7-17 years of age with a primary diagnosis of GAD were treated with flexibly dosed escitalopram (10-20 mg daily, = 138) or placebo ( = 137) for 8 weeks.
View Article and Find Full Text PDFImportance: Pathologic complete response (pCR) may be associated with prognosis in patients with soft tissue sarcoma (STS).
Objective: We sought to determine the prognostic significance of pCR on survival outcomes in STS for patients receiving neoadjuvant chemoradiotherapy (CT-RT) (Radiation Therapy Oncology Group [RTOG] 9514) or preoperative image-guided radiotherapy alone (RT, RTOG 0630) and provide a long-term update of RTOG 0630.
Design, Setting, And Participants: RTOG has completed 2 multi-institutional, nonrandomized phase 2 clinical trials for patients with localized STS.
Article Synopsis
- - The study aimed to compare the effectiveness of continuous infusion (CI) versus intermittent infusion (II) of ampicillin-sulbactam in maintaining appropriate drug levels in dogs with septic peritonitis, focusing on the percentage of time the drug concentration stayed above specific minimum inhibitory concentrations (MIC).
- - Eleven dogs were given either CI or II of ampicillin-sulbactam, and their serum levels were measured at various intervals. Both infusion methods successfully maintained drug levels above the lowest MIC tested (0.25 and 1.25 µg/mL), while CI showed somewhat better performance at higher MIC levels, though not statistically significant.
- - The study concluded that while continuous infusion might have slight advantages for higher
Statistical mechanics has grown without bounds in space. Statistical mechanics of noninteracting point particles in an unbounded perfect gas is widely used to describe liquids like concentrated salt solutions of life and electrochemical technology, including batteries. Liquids are filled with interacting molecules.
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