Publications by authors named "B Ebruke"
Article Synopsis
- The study investigated the prevalence and characteristics of human metapneumovirus (hMPV) in children with severe pneumonia across seven African and Asian countries, finding a significant correlation between hMPV and pneumonia cases compared to community controls.
- HMPV was more frequently detected in hospitalized pneumonia cases (6.9%) than in controls (2.3%), with a notable negative association with RSV and a positive association with bacterial infections.
- The majority of hMPV-positive cases were infants under one year, with low mortality rates similar to those of RSV-positive cases, indicating that hMPV pneumonia is challenging to distinguish from RSV pneumonia in clinical settings.
Introduction: In 2012, the World Health Organization revised treatment guidelines for childhood pneumonia with lower chest wall indrawing (LCWI) but no 'danger signs', to recommend home-based treatment. We analysed data from children hospitalized with LCWI pneumonia in the Pneumonia Etiology Research for Child Health (PERCH) study to identify sub-groups with high odds of mortality, who might continue to benefit from hospital management but may not be admitted by staff implementing the 2012 guidelines. We compare the proportion of deaths identified using the criteria in the 2012 guidelines, and the proportion of deaths identified using an alternative set of criteria from our model.
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- Diagnosis of bacterial meningitis in developing countries is complicated by low culture yields and non-prescription antibiotic use, prompting a study that compares traditional bacterial culture methods with the BioFire® FilmArray® Meningitis/Encephalitis Panel.
- The study analyzed 400 cerebrospinal fluid samples from children under five, finding that while 8% were culture positive, the BioFire ME Panel identified pathogens in 24.5% of culture-negative samples.
- The BioFire® ME Panel proved to be more sensitive and quicker than standard culture methods, successfully detecting both bacterial and viral agents associated with meningitis.
Infections caused by multi-drug resistant Enterobacterales (MDR-E) are difficult to treat and cause significant mortality, especially in developing countries. This study characterized the phenotypic and genotypic profiles of 49 randomly selected beta-lactam resistant MDR-E previously isolated from patients being managed in hospitals in Nigeria using whole genome sequencing. The study isolates exhibited 85.
View Article and Find Full Text PDFObjectives: Bacteremia due to invasive has been reported earlier in children in Nigeria. This study aimed to detect the virulence and antibiotic resistance genes of invasive from children with bacteremia in north-central Nigeria.
Method: From June 2015 to June 2018, 4163 blood cultures yielded 83 isolates.