Publications by authors named "B E Wade"
Article Synopsis
- CAR-T therapy has been effective for treating B cell lymphomas and leukaemias, leading to interest in its application for T cell malignancies.
- The treatment faces significant challenges, particularly because the target antigens are often found on both malignant and normal T cells, which can result in unintended damage to healthy cells.
- The review explores the latest clinical data on CAR-T treatment for T-ALL and T cell lymphomas, aiming to identify insights for future research and therapeutic strategies.
The Global ECT MRI Research Collaboration (GEMRIC) has collected clinical and neuroimaging data of patients treated with electroconvulsive therapy (ECT) from around the world. Results to date have focused on neuroimaging correlates of antidepressant response. GEMRIC sites have also collected longitudinal cognitive data.
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- Various species of campylobacters, including one causing spotty liver disease (SLD) in poultry, pose significant health and economic challenges, leading to high mortality and decreased egg production.
- Innovative genetic tools and methods were developed for manipulating the pathogen, including novel plasmid vectors and techniques for mutagenesis, which allowed for the study of important virulence factors.
- The study successfully inactivated a critical gene involved in glycosylation, demonstrating a powerful approach to further investigate the pathogen's virulence and potentially reduce reliance on antibiotics for disease control.
Introduction: Major depressive disorder (MDD) is associated with dysfunctional reward processing, which involves functional circuitry of the habenula (Hb) and nucleus accumbens (NAc). Since ketamine elicits rapid antidepressant and antianhedonic effects in MDD, this study sought to investigate how serial ketamine infusion (SKI) treatment modulates static and dynamic functional connectivity (FC) in Hb and NAc functional networks.
Methods: MDD participants (n = 58, mean age = 40.
Article Synopsis
- MRI is a key tool in researching diagnostic and prognostic markers after traumatic brain injury (TBI), particularly to understand mild TBI (mTBI), but findings are often inconsistent, highlighting the need for further study.
- The study analyzed MRI data from 976 military veterans and service members to explore the links between imaging outcomes and clinical features of mTBI, using regression models to account for factors like age and sex.
- Results indicated that while no major differences were found between those with and without mTBI history, blast-related mTBI showed significant brain volume reductions in certain areas, and multiple mTBIs correlated with specific MRI findings.