Publications by authors named "B E Swain"
The complex signaling network within the breast tumor microenvironment is crucial for its growth, metastasis, angiogenesis, therapy escape, stem cell maintenance, and immunomodulation. An array of secretory factors and their receptors activate downstream signaling cascades regulating breast cancer progression and metastasis. Among various signaling pathways, the EGFR, ER, Notch, and Hedgehog signaling pathways have recently been identified as crucial in terms of breast cancer proliferation, survival, differentiation, maintenance of CSCs, and therapy failure.
View Article and Find Full Text PDFArticle Synopsis
- Annexins are a group of proteins involved in calcium-mediated signaling, playing a key role in how plants respond to various stresses.
- This study focused on chickpeas (Cicer arietinum L.), identifying 13 annexin sequences in their genome and analyzing their structure and expression, revealing the presence of multiple exons and differential gene expression across different tissues.
- The research suggests that these annexins may influence plant growth and development during normal and stressful conditions, providing insights for further studies on their functions.
Current evidence on artificial intelligence in regional anesthesia.
World J Clin Cases
November 2024
Article Synopsis
- Recent advancements in regional anesthesia (RA) owe much to ultrasound technology, but human factors like fatigue and misidentification of anatomy can affect performance.
- Integrating artificial intelligence (AI) and machine learning can enhance RA practices by improving anatomical recognition and providing real-time guidance during procedures.
- While the future of AI in RA looks promising, challenges such as device malfunctions, data privacy issues, regulatory obstacles, and cost remain significant hurdles to widespread implementation.
The rise in surface air temperature (SAT) in Venezuela, leading to the loss of all its glaciers, underscores the urgency of understanding human contributions to this phenomenon. This study investigates the impact of anthropogenic climate forcings on SAT across Venezuela, employing observational data, multi-model simulations, and optimal fingerprinting method. Anthropogenic forcings have driven a 0.
View Article and Find Full Text PDFArticle Synopsis
- - O-GlcNAcylation is a crucial protein modification in cells regulated by two enzymes, OGT and OGA, and is linked to intellectual disabilities based on recent research.
- - A study using fruit flies with a specific mutation in the OGT enzyme revealed that low levels of O-GlcNAcylation cause issues with synapse formation and unstable sleep patterns.
- - These negative effects can be partially reversed by adjusting OGA levels, indicating that a proper balance between OGT and OGA is vital for healthy nerve development and function.