Publications by authors named "B E Shakhov"
Unlabelled: was to develop, evaluate, and validate an artificial neural network to predict coronary microvascular obstruction (CMVO) during percutaneous coronary interventions (PCI) in patients with myocardial infarctions (MI) based on the parameters, which are routinely available in an operating room when choosing a surgical approach.
Materials And Methods: 5621 patients with MI and emergency PCI were retrospectively selected from the database of the City Clinical Hospital No.13 (Nizhny Novgorod, Russia); among them, there were 3935 men (70%) and 1686 women (30%), their mean age was 61.
Article Synopsis
- Combined cross-polarization optical coherence tomography (CP OCT) and non-linear microscopy techniques are used to study collagen and elastin in atherosclerosis, focusing on identifying vulnerable plaques.
- CP OCT enhances visualization of tissue structure by revealing birefringence and cross-scattering, though these features can sometimes lead to ambiguous interpretations.
- The findings contribute to minimally invasive methods for characterizing and monitoring various stages of atherosclerosis, including misleading polarization artifacts in imaging that may not reflect true tissue characteristics.
The development of tumor therapies based on the activation of antitumor immunity requires tumor models that are highly immunogenic. The immunologic response to fluorescent proteins, green fluorescent protein (GFP), or enhanced GFP (EGFP) was demonstrated in different cancer models. However, for live animal imaging, red and far-red fluorescent proteins are preferable, but their immunogenicity has not been studied.
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- A technique called polarization-sensitive optical coherence tomography (OCT) is used for quantitative image analysis to diagnose bladder mucosal pathologies in live patients.
- The Integral Depolarization Factor (IDF) is a new image metric introduced to facilitate automatic diagnosis and assess the health of collagen fibers in the bladder.
- The IDF shows high diagnostic accuracy rates: 79% for severe fibrosis, 97% for detecting carcinoma recurrence, and 75% for distinguishing between neoplasia and acute inflammation, showing strong potential for use in human urology.
The purpose of this study was to evaluate photobleaching of the genetically encoded photosensitizer KillerRed in tumor spheroids upon pulsed and continuous wave (CW) laser irradiation and to analyze the mechanisms of cancer cell death after the treatment. We observed the light-dose dependent mechanism of KillerRed photobleaching over a wide range of fluence rates. Loss of fluorescence was limited to 80% at light doses of 150 J/cm(2) and more.
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