Publications by authors named "B E Pape"
: In this study, we review the diagnostic accuracy of magnetic resonance imaging (MRI) in detecting orbital and intracranial invasion of sinonasal malignancies (SNMs) using histopathological and surgical evidence as the reference standard. : A systematic search of studies in English was conducted in MEDLINE and Embase, limited to articles published since 1990. We included studies using preoperative MRI to detect the intracranial and orbital invasion of SNMs, with histological or surgical confirmation as the reference standard, and reported patient numbers in each class as required to assess diagnostic accuracy.
View Article and Find Full Text PDFBackground: Despite extensive vaccinations, pertussis remains endemic and epidemic in multiple countries. The persistence of cases can be partly attributed to the significant individual variation in vaccine responses. This study evaluated the association of baseline cytokines (before booster vaccination) on antibody concentrations to Tdap-vaccine antigens.
View Article and Find Full Text PDFObjective: The objective of this study was to develop and evaluate the feasibility and safety of a novel transaxial surgical approach for the delivery of human induced pluripotent stem cell-derived dopaminergic neuroprogenitor cells (DANPCs) into the putamen nucleus using nonhuman primates and surgical techniques and tools relevant to human clinical translation.
Methods: Nine immunosuppressed, unlesioned adult cynomolgus macaques (4 females, 5 males) received intraputaminal injections of vehicle or DANPCs (0.9 × 105 to 1.
Aim: The associations between the aetiology of preterm birth and later neurodevelopmental outcomes are unclear. A systematic review and meta-analysis examined the existing evidence.
Methods: The PubMed and Embase databases were searched for papers published in English from inception to 16 December 2020.
Article Synopsis
- The study evaluated how accurately MRI detects perineural spreading (PNS) of head and neck tumors, using histopathological or surgical evidence as the reference.
- Researchers analyzed 11 retrospective studies involving 245 patients, calculating metrics like sensitivity (85%) and specificity (85%) to assess MRI's diagnostic performance.
- Although MRI showed high accuracy for detecting PNS, the findings were based on limited and variable study data, with common characteristics like nerve enlargement and enhancement noted in affected nerves.