Publications by authors named "B E Jacobsen"
Purpose: The development of endocrine resistance remains a significant challenge in the clinical management of estrogen receptor-positive () breast cancer. Metabolic reprogramming is a prominent component of endocrine resistance and a potential therapeutic intervention point. However, a limited understanding of which metabolic changes are conserved across the heterogeneous landscape of ER+ breast cancer or how metabolic changes factor into ER DNA binding patterns hinder our ability to target metabolic adaptation as a treatment strategy.
View Article and Find Full Text PDF[Shortage antipsychotic medication supply hits vulnerable patients most].
Ned Tijdschr Geneeskd
October 2024
Article Synopsis
- - Medication shortages in The Netherlands have worsened since 2019, with increasing numbers reported annually, particularly affecting psychiatric medications.
- - In September 2023, a significant shortage of penfluridol and a long-term unavailability of olanzapine (Zypadhera) were experienced, impacting treatment options for patients.
- - These shortages pose serious risks, as interrupting or changing medications can lead to psychotic episodes, affecting patients’ mental stability and overall quality of life, prompting healthcare workers to emphasize the urgent need to address this issue.
Introduction: Patient and public involvement (PPI) in research integrates patient and public perspectives to improve research relevance and quality. The experiences of PPI partners have revealed mixed findings in countries where PPI is well established, but accounts from areas less accustomed to PPI in research are limited. This study aimed to explore the knowledge, motivations, expectations and experiences of PPI representatives in such a setting.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to analyze the distribution of hospital discharges related to alcohol diagnoses by sex and age, and to track how these discharges changed over time across various diagnostic categories in German hospitals from 2012 to 2021.
- Researchers performed a retrospective analysis on hospital discharges for patients aged 15-69, focusing on both primary and secondary alcohol-specific diagnoses, which were categorized using ICD-10 criteria.
- Findings revealed that out of over 95 million hospital discharges, about 3.8 million (4%) involved alcohol-related issues, with a higher incidence in men and among older age groups, while the overall rate of such discharges decreased more significantly in younger adults between 2012 and 2021.
Background And Objective: Iron deficiency affects more than 60% of colorectal cancer patients at the time of diagnosis. Iron deficiency ultimately leads to anemia, but additionally, iron deficiency might impact other domains of colorectal cancer patients' health and well-being. The aim of this study was to evaluate the impact of iron deficiency on fatigue, quality of life, cognition, and physical ability in patients undergoing evaluation for colorectal cancer.
View Article and Find Full Text PDF