APOBEC3A drives ovarian cancer metastasis by altering epithelial-mesenchymal transition.

High-grade serous ovarian cancer (HGSOC) is the most prevalent and aggressive histological subtype of ovarian cancer and often presents with metastatic disease. The drivers of metastasis in HGSOC remain enigmatic. APOBEC3A (A3A), an enzyme that generates mutations across various cancers, has been proposed as a mediator of tumor heterogeneity and disease progression.

Default Mode Network Detection using EEG in Real-time.

Mental health disorders affect countless people worldwide and present a major challenge for mental health services, which are struggling with the demand on a global scale. Recent studies have indicated that activity of the brain's Default Mode Network (DMN) could prove insightful in monitoring patient recovery from depression and has been used as a therapeutic target itself. An opportunity exists to replicate recent therapeutic protocols targeting DMN connectivity via functional magnetic resonance imaging using the more economically scalable modality of electroencephalogram (EEG).

Fractionated robotic radiosurgery for unfavorable nonfunctioning pituitary macroadenoma: 5-year outcomes from a single institution protocol.

Objective: Nonfunctioning macroadenoma is a commonly diagnosed pituitary tumor. Resection is the favored treatment, with radiosurgery often utilized for residual or progressing disease. Long-term outcomes are established in the literature for single-fraction frame-based radiosurgery, but mature outcomes are lacking for fractionated frameless radiosurgery.

Detection of diverse HIV strains by the m-PIMA HIV-1/2 detect point-of-care assay.

Background: HIV displays exceptionally high virus diversity that can impact detection by diagnostic assays, which rely on sequence conservation.

Methods: We tested the m-PIMA HIV-1/2 Detect point-of-care (POC) assay (Abbott Rapid Diagnostics) against a diverse HIV panel of 340 serum/plasma specimens and diluted cultured virus isolates for which viral load (VL) and classified sequences were known, including HIV-1 groups M, N, O, P, Circulating Recombinant Forms (CRF), and Unique Recombinant Forms (URF), and HIV-2. An in silico inclusivity analysis of 53,503 HIV-1 and 68 HIV-2 sequences from NCBI was performed to predict performance of m-PIMA HIV-1/2 Detect against a broader range of circulating strains.

Wnt signaling inhibits casein kinase 1α activity by modulating its interaction with protein phosphatase 2A.

The mechanism by which Wnt signaling, an essential pathway controlling development and disease, stabilizes β-catenin has been a subject of debate over the last four decades. Casein kinase 1α (CK1α) functions as a pivotal negative regulator of this signaling pathway, initiating the events that destabilize β-catenin. However, whether and how CK1α activity is regulated in Wnt-off and Wnt-on states remains poorly understood.